Nathan T. Ross

TL;DR: The data suggest that FPS-ZM1 is a potent multimodal RAGE blocker that effectively controls progression of Aβ-mediated brain disorder and that it may have the potential to be a disease-modifying agent for AD.

TL;DR: In this paper, the authors developed a high-throughput screening platform for primary human hepatocytes to identify small molecules in two different classes that can be used to generate renewable sources of functional human hepatocyte.

TL;DR: An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules, leading to the discovery of a novel class of histone deacetylase inhibitors, and led to increased levels of acetylation in a primary mouse neuron culture.

TL;DR: A high-throughput screening platform for primary human hepatocytes is developed to identify small molecules in two different classes that can be used to generate renewable sources of functional human liver cells in vitro.

TL;DR: A high-throughput screen using compounds in the Molecular Libraries Small Molecule Repository led to the chemical probe ML281, which showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK 33 inhibitors that were reported in the course of these studies.