J
Jing Xing
Researcher at Michigan State University
Publications - 37
Citations - 817
Jing Xing is an academic researcher from Michigan State University. The author has contributed to research in topics: Virtual screening & Medicine. The author has an hindex of 13, co-authored 28 publications receiving 480 citations. Previous affiliations of Jing Xing include East China University of Science and Technology & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Published anti-SARS-CoV-2 in vitro hits share common mechanisms of action that synergize with antivirals.
Jing Xing,Shreya Paithankar,Ke Liu,Katie L. Uhl,Xiaopeng Li,Meehyun Ko,Seungtaek Kim,Jeremy Haskins,Bin Chen +8 more
TL;DR: In this paper, the authors found that 36% of the active compounds regulate genes related to cholesterol homeostasis and microtubule cytoskeleton organization, which is associated with COVID-19 patient severity and has predictive power on anti-SARS-CoV-2 efficacy in vitro.
Journal ArticleDOI
Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family.
Fei Li,Xiaozhe Wan,Jing Xing,Jing Xing,Xiaoqin Tan,Xutong Li,Yulan Wang,Jihui Zhao,Xiaolong Wu,Xiaolong Wu,Xiaohong Liu,Xiaohong Liu,Zhaojun Li,Xiaomin Luo,Wencong Lu,Mingyue Zheng +15 more
TL;DR: A target-specific scoring model is reported for compound VS, which predict the likelihood of the compound being a potential inhibitor for the SAM-binding pocket of a given methyltransferase.
Posted ContentDOI
Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19
Mengying Sun,Rama Shankar,Meehyun Ko,Christopher Daniel Chang,Shan-Ju Yeh,Shilong Li,Ke Liu,Guoli Zhou,Jing Xing,Austin VanVelsen,Tyler VanVelsen,Shreya Paithankar,Benjamin Y. Feng,Krista Young,Michael Strug,Lauren Turco,Zichen Wang,Eric E. Schadt,Rong Chen,Xiaohong Li,Tomiko Oskotsky,Marina Sirota,Benjamin S. Glicksberg,Girish N. Nadkarni,Adam J. Moeser,Li Li,Seungtaek Kim,Jiayu Zhou,Bin Chen +28 more
TL;DR: Using over 220,000 human gene expression profiles covering a wide range of age, tissues, and diseases, it is found that male samples show higher expression levels of ACE2 and TMPRSS2, especially in the older group (>60 years) and in the kidney.
Proceedings ArticleDOI
MolSearch: Search-based Multi-objective Molecular Generation and Property Optimization
TL;DR: It is shown that given proper design and sufficient domain information, search-based methods can achieve performance comparable or even better than deep learning methods while being computationally efficient.
Posted ContentDOI
Gene expression signatures identify pediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit
Rama Shankar,Mara Leimanis,Mara Leimanis,Patrick A. Newbury,Ke Liu,Jing Xing,Derek Nedveck,Eric J. Kort,Eric J. Kort,Eric J. Kort,Jeremy W. Prokop,Guoli Zhou,André S. Bachmann,Bin Chen,Surender Rajasekaran,Surender Rajasekaran,Surender Rajasekaran +16 more
TL;DR: This study identified lower neutrophils and upregulation of specific histone related genes as a putative signature for deterioration of MODS to ECMO.