Z
Zhechu Peng
Researcher at University of Southern California
Publications - 8
Citations - 159
Zhechu Peng is an academic researcher from University of Southern California. The author has contributed to research in topics: Protein kinase B & PTEN. The author has an hindex of 5, co-authored 7 publications receiving 116 citations.
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Journal ArticleDOI
Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.
Anketse Debebe,Vivian Medina,C. Y. Chen,I. M. Mahajan,C. Jia,C. Jia,D. Fu,Lina He,Ni Zeng,B. W. Stiles,Chien-Yu Chen,M. Wang,K. R. Aggarwal,Zhechu Peng,Jen-Ming Huang,Jingyu Chen,Meng Li,T. Dong,S. Atkins,Zea Borok,W. Yuan,K. Machida,Changqing Ju,Michael Kahn,Deborah L. Johnson,Bangyan L. Stiles +25 more
TL;DR: Wnt/β-catenin is established as a novel signal produced by infiltrating macrophages induced by steatosis that promotes growth of tumor progenitor cells, underlying the increased risk of liver tumor development in obese individuals.
Journal ArticleDOI
Activation of hepatic stellate cell in Pten null liver injury model
Lina He,James Gubbins,Zhechu Peng,Vivian Medina,Fan Fei,Kinji Asahina,Jiaohong Wang,Michael Kahn,Carl B. Rountree,Bangyan L. Stiles +9 more
TL;DR: Wnt/β-catenin activation serves as an important mediator for fibrosis development resulting from NASH using a mouse model where NASH is mimicked by PTEN loss.
Journal ArticleDOI
Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice
Kai-Ting Yang,Jennifer-Ann Bayan,Ni Zeng,Richa Aggarwal,Lina He,Zhechu Peng,Anketse Kassa,Melissa Kim,Zhiou Luo,Zhenrong Shi,Vivian Medina,Keerthi Boddupally,Bangyan L. Stiles +12 more
TL;DR: Deletion of Pten in juvenile beta cells significantly induced their proliferation and increased islet mass, and a novel finding suggests that PTEN-regulated mechanisms may override the age-onset diminished ability of beta cells to respond to mitogenic stimulation.
Journal ArticleDOI
AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells.
Zhechu Peng,Richa Aggarwal,Ni Zeng,Lina He,Eileen X. Stiles,Anketse Debebe,Jingyu Chen,Chien-Yu Chen,Bangyan L. Stiles +8 more
TL;DR: It is shown that AKT1 protein loss led to the induction of eukaryotic initiation factor 2 α subunit (eIF2α) signaling and ER stress markers under normal-chow-fed conditions, indicating chronic low-level ER stress.
Journal ArticleDOI
Crosstalk Between Activated Myofibroblasts and β Cells in Injured Mouse Pancreas.
TL;DR: Investigating the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic islets suggests that that these mesenchymal cells may support the regeneration of the islets.