J
Jaekwang Kim
Researcher at Washington University in St. Louis
Publications - 24
Citations - 6407
Jaekwang Kim is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Neurodegeneration & Medicine. The author has an hindex of 12, co-authored 21 publications receiving 5898 citations. Previous affiliations of Jaekwang Kim include University of Minnesota & Seoul National University.
Papers
More filters
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
Journal ArticleDOI
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
David Ramonet,João Paulo Lima Daher,João Paulo Lima Daher,Brian M. Lin,Klodjan Stafa,Jaekwang Kim,Jaekwang Kim,Rebecca Banerjee,Marie Westerlund,Olga Pletnikova,Liliane Glauser,Lichuan Yang,Ying Liu,Deborah A. Swing,M. Flint Beal,Juan C. Troncoso,J. Michael McCaffery,Nancy A. Jenkins,Nancy A. Jenkins,Neal G. Copeland,Neal G. Copeland,Dagmar Galter,Bobby Thomas,Michael K. Lee,Michael K. Lee,Ted M. Dawson,Valina L. Dawson,Darren J. Moore +27 more
TL;DR: This study demonstrates that expression of G2019S mutant LRRK2 induces the degeneration of nigrostriatal pathway dopaminergic neurons in an age-dependent manner, and will provide important tools for understanding the mechanism(s) through which familial mutations precipitate neuronal degeneration and PD.
Journal ArticleDOI
Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide
Anuj K. Sharma,Stephanie T. Pavlova,Jaekwang Kim,Darren S. Finkelstein,Nicholas J. Hawco,Nigam P. Rath,Jungsu Kim,Liviu M. Mirica +7 more
TL;DR: The results suggest that the previously employed strategy of inhibiting Aβ aggregation and promoting amyloid fibril dissagregation may not be optimal for the development of potential AD therapeutics, due to formation of neurotoxic soluble Aβ(42) oligomers.
Journal ArticleDOI
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
Jungsu Kim,Adam E.M. Eltorai,Hong Jiang,Fan Liao,Philip B. Verghese,Jaekwang Kim,Floy R. Stewart,Jacob M. Basak,David M. Holtzman +8 more
TL;DR: An anti-ApoE antibody reduces amyloid deposition and enhances the microglial response to Aβ plaques in an Alzheimer’s disease mouse model.
Journal ArticleDOI
The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity
TL;DR: The data presented herein including cellular toxicity studies strongly suggest that Cu(2+) increases the neurotoxicity of A β42 due to stabilization of soluble Aβ42 oligomers.