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Fibre lasers in the mid-infrared regime are useful for a diverse range of fields, including chemical and biomedical sensing, military applications and materials processing. This Review summarizes the different rare-earth cations and host materials used in mid-infrared fibre laser technology, and discusses the future applications and challenges for the field.

Towards high-power mid-infrared emission from a fibre laser

Infrared (2–12 μm) solid-state laser sources: a review

Fiber lasers have seen progressive developments in terms of spectral coverage and linewidth, output power, pulse energy, and ultrashort pulse width since the first demonstration of a glass fiber laser in 1964. Their applications have extended into a variety of fields accordingly. In this paper, the milestones of glass fiber laser development are briefly reviewed and recent advances of high-power continuous wave, Q-switched, mode-locked, and single-frequency fiber lasers in the 1, 1.5, 2, and 3 μm regions and their applications in such areas as industry, medicine, research, defense, and security are addressed in detail.

Fiber lasers and their applications [Invited]

In this review we discuss the application of laser-induced breakdown spectroscopy (LIBS) to the problem of detection of residues of explosives. Research in this area presented in open literature is reviewed. Both laboratory and field-tested standoff LIBS instruments have been used to detect explosive materials. Recent advances in instrumentation and data analysis techniques are discussed, including the use of double-pulse LIBS to reduce air entrainment in the analytical plasma and the application of advanced chemometric techniques such as partial least-squares discriminant analysis to discriminate between residues of explosives and non-explosives on various surfaces. A number of challenges associated with detection of explosives residues using LIBS have been identified, along with their possible solutions. Several groups have investigated methods for improving the sensitivity and selectivity of LIBS for detection of explosives, including the use of femtosecond-pulse lasers, supplemental enhancement of the laser-induced plasma emission, and complementary orthogonal techniques. Despite the associated challenges, researchers have demonstrated the tremendous potential of LIBS for real-time detection of explosives residues at standoff distances.

Laser-induced breakdown spectroscopy for detection of explosives residues: a review of recent advances, challenges, and future prospects

Double-pulsed 2-μm integrated path differential absorption (IPDA) lidar is well suited for atmospheric CO2 remote sensing. The IPDA lidar technique relies on wavelength differentiation between strong and weak absorbing features of the gas normalized to the transmitted energy. In the double-pulse case, each shot of the transmitter produces two successive laser pulses separated by a short interval. Calibration of the transmitted pulse energies is required for accurate CO2 measurement. Design and calibration of a 2-μm double-pulse laser energy monitor is presented. The design is based on an InGaAs pin quantum detector. A high-speed photoelectromagnetic quantum detector was used for laser-pulse profile verification. Both quantum detectors were calibrated using a reference pyroelectric thermal detector. Calibration included comparing the three detection technologies in the single-pulsed mode, then comparing the quantum detectors in the double-pulsed mode. In addition, a self-calibration feature of the 2-μm IPDA lidar is presented. This feature allows one to monitor the transmitted laser energy, through residual scattering, with a single detection channel. This reduces the CO2 measurement uncertainty. IPDA lidar ground validation for CO2 measurement is presented for both calibrated energy monitor and self-calibration options. The calibrated energy monitor resulted in a lower CO2 measurement bias, while self-calibration resulted in a better CO2 temporal profiling when compared to the in situ sensor.

Self-calibration and laser energy monitor validations for a double-pulsed 2-μm CO 2 integrated path differential absorption lidar application.

A 2-µm wavelength coherent Doppler lidar for wind measurement has been developed of an unprecedented laser pulse energy of 250-mJ in a rugged package. This high pulse energy is produced by a Ho:Tm:LuLiF laser with an optical amplifier. While the lidar is meant for use as an airborne instrument, ground-based tests were carried out to characterize performance of the lidar. Atmospheric measurements are presented, showing the lidar's capability for wind measurement in the atmospheric boundary layer and free troposphere. Lidar wind measurements are compared to a balloon sonde, showing good agreement between the two sensors.

Field testing of a high-energy 2-μm Doppler lidar

A single frequency fiber laser operating near 2 micron with over 50 mW output power has been demonstrated by using a short piece of newly developed single mode holmium-doped germanate glass fiber. Laser from 2004 nm to 2083 nm was demonstrated from a short Ho-doped fiber laser cavity. A heavily thulium-doped germanate fiber was used as an in-band pump source for the holmium-doped fiber laser. The single frequency fiber laser can be thermally tuned.

Single frequency fiber laser at 2.05 μm based on Ho-doped germanate glass fiber

It has been noticed in recent years that the unfavorable effects of the gut microbiota could exhaust host vigor and life, yet knowledge and theory are just beginning to be established. Increasing documentation suggests that the microbiota–gut–brain axis not only impacts brain cognition and psychiatric symptoms but also precipitates neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). How the blood–brain barrier (BBB), a machinery protecting the central nervous system (CNS) from the systemic circulation, allows the risky factors derived from the gut to be translocated into the brain seems paradoxical. For the unique anatomical, histological, and immunological properties underpinning its permeable dynamics, the BBB has been regarded as a biomarker associated with neural pathogenesis. The BBB permeability of mice and rats caused by GM dysbiosis raises the question of how the GM and its metabolites change BBB permeability and causes the brain pathophysiology of neuroinflammation and neurodegeneration (NF&ND) and brain aging, a pivotal multidisciplinary field tightly associated with immune and chronic systemic inflammation. If not all, gut microbiota-induced systemic chronic inflammation (GM-SCI) mainly refers to excessive gut inflammation caused by gut mucosal immunity dysregulation, which is often influenced by dietary components and age, is produced at the interface of the intestinal barrier (IB) or exacerbated after IB disruption, initiates various common chronic diseases along its dispersal routes, and eventually impairs BBB integrity to cause NF&ND and brain aging. To illustrate the immune roles of the BBB in pathophysiology affected by inflammatory or “leaky” IB resulting from GM and their metabolites, we reviewed the selected publications, including the role of the BBB as the immune barrier, systemic chronic inflammation and inflammation influences on BBB permeability, NF&ND, and brain aging. To add depth to the bridging role of systemic chronic inflammation, a plausible mechanism indispensable for BBB corruption was highlighted; namely, BBB maintenance cues are affected by inflammatory cytokines, which may help to understand how GM and its metabolites play a major role in NF&ND and aging.

Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging

This study reports airborne measurements of atmospheric CO2 column density using a 2-μm double-pulsed integrated path differential absorption (IPDA) lidar. This new 2-μm IPDA lidar offers an alternative approach to measure CO2 column density with unique features. The online frequencies of this lidar can be tuned to 1–6 GHz from the CO2 R30 absorption line peak. It provides high measurement sensitivity to the lower-tropospheric CO2 near the ground surface. This instrument was flown in the spring of 2014 in a NASA B200 aircraft. The results of these test flights clearly demonstrate the measurement capabilities of this lidar instrument. The CO2 column dry mixing ratio is compared to an in situ CO2 measurement by a collocated NOAA flight. The IPDA lidar measurement is determined to be in good agreement with a 0.36% difference, which corresponds to 1.48 ppm. It is the average difference between the IPDA lidar measurements and the NOAA air samples in the flight altitudes from 3 to 6.1 km.

Jirong Yu

Papers

Self-calibration and laser energy monitor validations for a double-pulsed 2-μm CO 2 integrated path differential absorption lidar application.

Field testing of a high-energy 2-μm Doppler lidar

Single frequency fiber laser at 2.05 μm based on Ho-doped germanate glass fiber

Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging

An Airborne 2-μm Double-Pulsed Direct-Detection Lidar Instrument for Atmospheric CO2 Column Measurements