Jo Ann M. Mican

TL;DR: Highly purified CD4+ T cells from patients receiving HAART with an average treatment time of 10 months and with undetectable plasma viremia carried integrated proviral DNA and were capable of producing infectious virus upon cellular activation in vitro, suggesting persistent active virus replication in vivo.

TL;DR: These results establish an effector function and mechanism that clearly segregate with immunologic control of HIV and demonstrate that lytic granule contents of memory cells are a critical determinant of cytotoxicity that must be induced for maximal per-cell killing capacity.

TL;DR: Results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease.

TL;DR: A spectrum of urinary tract findings in patients treated with indinavir is reported, most common is asymptomatic crystalluria associated with dysuria, urgency, back and flank pain, and renal colic, while some patients with back or flank pain had radiographic evidence of renal parenchymal defects.

TL;DR: Suppression of proliferation of HIV-specific CD4+ T cells in the context of high levels of antigen may be a mechanism by which HIV or other persistently replicating viruses limit the precursor frequency of virus- specific CD4- T cells and disrupt the development of effective virus-specific immune responses.