Joan-Josep Bech-Serra

TL;DR: The MIAPE Quant guidelines describe the HUPO-PSI proposal concerning the minimum information to be reported when a quantitative data set, derived from mass spectrometry (MS), is submitted to a database or as supplementary information to a journal.

TL;DR: In this article, the authors characterized the oxidative folding of Cox19, a twin CX9C Mia40 substrate, and showed that Mia40 accelerates Cox19 folding through specific recognition of the third Cys in the second helical CX 9C motif and subsequent oxidation of the inner disulfide bond.

TL;DR: Phosphoproteomics of Cdc55-deficient cells is used to uncover new PP2ACdc55 substrates and functions in mitosis, and Pkc1 emerged as a novel node of PP2 ACdc55 regulation, highlighting a major role ofPP2ACDC55 in actin cytoskeleton and cytokinesis, gene ontology terms significantly enriched in the PP2DC55-dependent phosphoproteome.

TL;DR: This work characterize the disorder-to-order transition of a Mia40 substrate, the human small copper chaperone Cox17, and demonstrates that in this mitochondrial protein, the conformational switch between disordered and folded states is controlled by the formation of a single disulfide bond.

TL;DR: A multi-laboratory study was set up, performed at 12 laboratories of the ProteoRed network (Spanish network of proteomics facilities) to assess the reproducibility of 2DE experiments across laboratories.