João S. Teodoro

TL;DR: Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas SIRT1 knockouts displayed none of these benefits, whereas a mouse overexpressing Sirt1 mimicked these effects.

TL;DR: It is shown that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits, and an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age.

TL;DR: Stimulation of mitochondrial function may also prevent NASH development, protecting the cell against the increased flux of reduced substrates to the ETC and ROS generation.

TL;DR: The results show that silver nanoparticles cause impairment of mitochondrial function, due mainly to alterations of mitochondrial membrane permeability, which results in an uncoupling effect on the oxidative phosphorylation system.

TL;DR: It is shown that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis, and an important role for SIRT1 and mitochondrialBiogenesis in the preventive effects of BBR on diet-induced insulin resistance.