M
Magdalene K. Montgomery
Researcher at University of Melbourne
Publications - 52
Citations - 3475
Magdalene K. Montgomery is an academic researcher from University of Melbourne. The author has contributed to research in topics: Insulin resistance & Lipid metabolism. The author has an hindex of 20, co-authored 45 publications receiving 2533 citations. Previous affiliations of Magdalene K. Montgomery include Monash University & Garvan Institute of Medical Research.
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Journal ArticleDOI
Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes,Ana P. Gomes,Nathan L. Price,Alvin J. Y. Ling,Javid Moslehi,Magdalene K. Montgomery,Luis A. Rajman,James P. White,João S. Teodoro,Christiane D. Wrann,Basil P. Hubbard,Evi M. Mercken,Carlos M. Palmeira,Rafael de Cabo,Anabela P. Rolo,Nigel Turner,Eric L. Bell,David A. Sinclair,David A. Sinclair +18 more
TL;DR: It is shown that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits, and an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age.
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Mitochondrial dysfunction and insulin resistance: an update
TL;DR: A journey through the past is taken and the debate about the occurrence of mitochondrial dysfunction and its possible role in causing decreased insulin action in obesity and type 2 diabetes is summarised.
Journal ArticleDOI
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
Magdalene K. Montgomery,Nicole L Hallahan,Simon H. J. Brown,Menghan Liu,Todd W. Mitchell,Gregory J. Cooney,Gregory J. Cooney,Nigel Turner,Nigel Turner +8 more
TL;DR: Findings indicate that most mouse strains develop metabolic defects on an HFD, however, there are inherent differences between strains, and thus the genetic background needs to be considered carefully in metabolic studies.
Journal ArticleDOI
The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance.
TL;DR: The NAFLD-induced changes in secretion of liver proteins, lipids, other metabolites, and miRNAs are described, and how these molecules alter metabolism in liver, muscle, adipose tissue and pancreas to induce insulin resistance is described.
Journal ArticleDOI
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Matthew J. Watt,Matthew J. Watt,Ashlee K. Clark,Luke A. Selth,Vanessa R. Haynes,Vanessa R. Haynes,Natalie Lister,Richard J. Rebello,Richard J. Rebello,Laura H Porter,Birunthi Niranjan,Sarah T. Whitby,Jennifer Chi Yi Lo,Cheng Huang,Ralf B. Schittenhelm,Kimberly E. Anderson,Luc Furic,Poornima R. Wijayaratne,Maria Matzaris,Magdalene K. Montgomery,Magdalene K. Montgomery,Melissa Papargiris,Sam Norden,Maria Febbraio,Gail P. Risbridger,Mark Frydenberg,Daniel K. Nomura,Renea A. Taylor,Renea A. Taylor +28 more
TL;DR: A critical role is identified for CD36-mediated fatty acid uptake in prostate cancer and targeted targeting of these pathways more potently inhibited proliferation of human cancer-derived organoids compared to the single treatments.