J
Joel M. Palefsky
Researcher at University of California, San Francisco
Publications - 418
Citations - 32334
Joel M. Palefsky is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Anal cancer & HPV infection. The author has an hindex of 92, co-authored 397 publications receiving 29038 citations. Previous affiliations of Joel M. Palefsky include Howard Hughes Medical Institute & Centers for Disease Control and Prevention.
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Journal ArticleDOI
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
Janice S. Chen,Enbo Ma,Lucas B. Harrington,Maria Da Costa,Xinran Tian,Joel M. Palefsky,Jennifer A. Doudna +6 more
TL;DR: It is shown that RNA-guided DNA binding unleashes indiscriminate single-stranded DNA cleavage activity by Cas12a that completely degrades ssDNA molecules, which is also a property of other type V CRISPR-Cas12 enzymes.
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Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males
Anna R. Giuliano,Joel M. Palefsky,Stephen E. Goldstone,Edson D. Moreira,Mary E. Penny,Carlos Aranda,Eftyhia Vardas,Harald Moi,Heiko Jessen,Richard J. Hillman,Yen Hwa Chang,Daron G. Ferris,Danielle Rouleau,Janine T. Bryan,J. Brooke Marshall,Scott Vuocolo,Eliav Barr,David Radley,Richard M. Haupt,Dalya Guris +19 more
TL;DR: Quadrivalent HPV vaccine prevents infection with HPV-6, 11, 16, and 18 and the development of related external genital lesions in males 16 to 26 years of age.
Journal ArticleDOI
HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia
Joel M. Palefsky,Anna R. Giuliano,Stephen E. Goldstone,Edson D. Moreira,Carlos Aranda,Heiko Jessen,Richard J. Hillman,Daron G. Ferris,François Coutlée,Mark H. Stoler,J. Brooke Marshall,David Radley,Scott Vuocolo,Richard M. Haupt,Dalya Guris,Elizabeth I.O. Garner +15 more
TL;DR: Use of the qHPV vaccine reduced the rates of anal intraepithelial neoplasia, including of grade 2 or 3, among men who have sex with men and had a favorable safety profile and may help to reduce the risk of anal cancer.
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The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
Teresa M. Darragh,Terence J. Colgan,J. Thomas Cox,Debra S. Heller,Michael R. Henry,Ronald D. Luff,Ronald D. Luff,Timothy H. McCalmont,Ritu Nayar,Joel M. Palefsky,Mark H. Stoler,Edward J. Wilkinson,Richard J. Zaino,David C. Wilbur +13 more
TL;DR: The Lower Anogenital Squamous Terminology (LAST) Project as mentioned in this paper was created to create a histopathologic nomenclature system that reflects current knowledge of human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract.
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Risks for Incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young Females
Anna-Barbara Moscicki,Nancy K. Hills,Steve Shiboski,Kim Powell,Naomi Jay,Evelyn Hanson,Susanna B. Miller,Lisa Clayton,Sepideh Farhat,Jeanette M. Broering,Teresa M. Darragh,Joel M. Palefsky +11 more
TL;DR: Risks of incident HPV infection in HPV-negative females and of incident LSIL development in females with HPV infection are examined, indicating distinct risks for HPV and LSIL.