J
Joelle M. van der Walt
Researcher at Duke University
Publications - 10
Citations - 1855
Joelle M. van der Walt is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Haplotype. The author has an hindex of 10, co-authored 10 publications receiving 1780 citations. Previous affiliations of Joelle M. van der Walt include National Institutes of Health.
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Journal ArticleDOI
Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease
Joelle M. van der Walt,Kristin K. Nicodemus,Eden R. Martin,William K. Scott,Martha Nance,Ray L. Watts,Jean P. Hubble,Jonathan L. Haines,William C. Koller,Kelly E. Lyons,Rajesh Pahwa,Matthew B. Stern,Amy Colcher,Bradley C. Hiner,Joseph Jankovic,William G. Ondo,Fred H. Allen,Christopher G. Goetz,Gary W. Small,Frank L. Mastaglia,Jeffrey M. Stajich,Adam C. McLaurin,Lefkos T. Middleton,Burton L. Scott,Donald E. Schmechel,Margaret A. Pericak-Vance,Jeffery M. Vance +26 more
TL;DR: The results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression.
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Variation in the miRNA-433 Binding Site of FGF20 Confers Risk for Parkinson Disease by Overexpression of α-Synuclein
Gaofeng Wang,Joelle M. van der Walt,Gregory Mayhew,Yi-Ju Li,Stephan Züchner,William K. Scott,Eden R. Martin,Jeffery M. Vance +7 more
TL;DR: A novel mechanism of action is suggested for PD risk in which the modulation of the susceptibility gene's translation by common variations interfere with the regulation mechanisms of microRNA.
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Analysis of European mitochondrial haplogroups with Alzheimer disease risk
Joelle M. van der Walt,Yulia Dementieva,Eden R. Martin,William K. Scott,Kristin K. Nicodemus,Charles C. Kroner,Kathleen A. Welsh-Bohmer,Ann M. Saunders,Allen D. Roses,Gary W. Small,Donald E. Schmechel,P. Murali Doraiswamy,John R. Gilbert,Jonathan L. Haines,Jeffery M. Vance,Margaret A. Pericak-Vance +15 more
TL;DR: The results were independent of APOE genotype, demonstrating that the effect of mt variation is not confounded by APOE4 carrier status, and suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE.
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Phylogeography and genetic ancestry of tigers (Panthera tigris).
Shu-Jin Luo,Shu-Jin Luo,Jae Heup Kim,Jae Heup Kim,Warren E. Johnson,Joelle M. van der Walt,Joelle M. van der Walt,Janice S. Martenson,Naoya Yuhki,Dale G. Miquelle,Olga Uphyrkina,John M. Goodrich,Howard B. Quigley,Ronald Tilson,Gerald Brady,Paolo Martelli,Vellayan Subramaniam,Charles McDougal,Sun Hean,Shi Qiang Huang,Wenshi Pan,Ullas K. Karanth,Melvin E. Sunquist,James L. Smith,Stephen J. O'Brien +24 more
TL;DR: To investigate the species' evolutionary history and to establish objective methods for subspecies recognition, voucher specimens of blood, skin, hair, and/or skin biopsies from 134 tigers with verified geographic origins or heritage across the whole distribution range were examined for molecular markers.
Journal ArticleDOI
Fibroblast Growth Factor 20 Polymorphisms and Haplotypes Strongly Influence Risk of Parkinson Disease
Joelle M. van der Walt,Maher A. Noureddine,Raja Kittappa,Michael A. Hauser,William K. Scott,Ronald D.G. McKay,Fengyu Zhang,Jeffrey M. Stajich,Kenichiro Fujiwara,Burton L. Scott,Margaret A. Pericak-Vance,Jeffery M. Vance,Eden R. Martin +12 more
TL;DR: The results strongly support FGF20 as a risk factor for Parkinson disease, with a highly significant association of PD with one intronic SNP, rs1989754, and two SNPs located in the 3' regulatory region in the overall sample.