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Bradley C. Hiner
Researcher at Medical College of Wisconsin
Publications - 28
Citations - 3312
Bradley C. Hiner is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Genetic linkage & Single-nucleotide polymorphism. The author has an hindex of 21, co-authored 28 publications receiving 3123 citations. Previous affiliations of Bradley C. Hiner include Marshfield Clinic & Johns Hopkins University.
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Journal ArticleDOI
Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease
Joelle M. van der Walt,Kristin K. Nicodemus,Eden R. Martin,William K. Scott,Martha Nance,Ray L. Watts,Jean P. Hubble,Jonathan L. Haines,William C. Koller,Kelly E. Lyons,Rajesh Pahwa,Matthew B. Stern,Amy Colcher,Bradley C. Hiner,Joseph Jankovic,William G. Ondo,Fred H. Allen,Christopher G. Goetz,Gary W. Small,Frank L. Mastaglia,Jeffrey M. Stajich,Adam C. McLaurin,Lefkos T. Middleton,Burton L. Scott,Donald E. Schmechel,Margaret A. Pericak-Vance,Jeffery M. Vance +26 more
TL;DR: The results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression.
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Neurogenic orthostatic hypotension: A double-blind, placebo-controlled study with midodrine
Joseph Jankovic,Janice L Gilden,Bradley C. Hiner,Horacio Kaufmann,David C. Brown,Cecil Coghlan,Michael Rubin,Fetnat M. Fouad-Tarazi +7 more
TL;DR: Midodrine is an effective and well-tolerated treatment for moderate-to-severe orthostatic hypotension associated with autonomic failure and the overall side effects were mainly mild to moderate.
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Age at onset in two common neurodegenerative diseases is genetically controlled
Yi-Ju Li,William K. Scott,Dale J. Hedges,Fengyu Zhang,P. Craig Gaskell,Martha Nance,Ray L. Watts,Jean P. Hubble,William C. Koller,Rajesh Pahwa,Matthew B. Stern,Bradley C. Hiner,Joseph Jankovic,Fred H. Allen,Christopher G. Goetz,Frank L. Mastaglia,Jeffrey M. Stajich,Rachel A. Gibson,Lefkos T. Middleton,Ann M. Saunders,Burton L. Scott,Gary W. Small,Kristin K. Nicodemus,Allison D. Reed,Donald E. Schmechel,Kathleen A. Welsh-Bohmer,P. Michael Conneally,Allen D. Roses,John R. Gilbert,Jeffery M. Vance,Jonathan L. Haines,Margaret A. Pericak-Vance +31 more
TL;DR: The data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.
Journal ArticleDOI
Complete genomic screen in Parkinson disease: evidence for multiple genes.
William K. Scott,Martha Nance,Ray L. Watts,Jean P. Hubble,William C. Koller,Kelly E. Lyons,Rajesh Pahwa,Matthew B. Stern,Amy Colcher,Bradley C. Hiner,Joseph Jankovic,William G. Ondo,Fred H. Allen,Christopher G. Goetz,Gary W. Small,Donna Masterman,Frank L. Mastaglia,Nigel G. Laing,Jeffrey M. Stajich,Brandon D. Slotterbeck,Michael W. Booze,Robert C. Ribble,Evadnie Rampersaud,Sandra G. West,Rachel A. Gibson,Lefkos T. Middleton,Allen D. Roses,Jonathan L. Haines,Burton L. Scott,Jeffery M. Vance,Margaret A. Pericak-Vance +30 more
TL;DR: The data suggest that the parkin gene is important in early-onset PD and that multiple genetic factors may be important in the development of idiopathic late-ONSet PD.
Journal ArticleDOI
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
Yi-Ju Li,Sofia A. Oliveira,Pu-Ting Xu,Eden R. Martin,Judith E. Stenger,Clemens R. Scherzer,Michael A. Hauser,William K. Scott,Gary W. Small,Martha Nance,Ray L. Watts,Jean P. Hubble,William C. Koller,Rajesh Pahwa,Mathew B. Stern,Bradley C. Hiner,Joseph Jankovic,Christopher G. Goetz,Frank L. Mastaglia,Lefkos T. Middleton,Allen D. Roses,Ann M. Saunders,Donald E. Schmechel,Steven R. Gullans,Jonathan L. Haines,John R. Gilbert,Jeffrey M. Vance,Margaret A. Pericak-Vance +27 more
TL;DR: Genetic linkage of loci controlling age-at-onset in Alzheimer disease and Parkinson's disease to a 15 cM region on chromosome 10q was reported and the process of 'genomic convergence' was applied to prioritize and reduce the number of candidate genes for further analysis.