J
Joerg J. Jacoby
Researcher at Yale University
Publications - 2
Citations - 279
Joerg J. Jacoby is an academic researcher from Yale University. The author has contributed to research in topics: Proinflammatory cytokine & STAT protein. The author has an hindex of 2, co-authored 2 publications receiving 249 citations.
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Journal ArticleDOI
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.
Arihiro Kano,Michael J. Wolfgang,Qian Gao,Joerg J. Jacoby,Gui Xuan Chai,William Hansen,Yoshiki Iwamoto,Yoshiki Iwamoto,Jordan S. Pober,Richard A. Flavell,Xin-Yuan Fu +10 more
TL;DR: It is shown that a soluble activity derived from endothelia and dependent on STAT3 is critical for suppression of interferon γ, and this data define STAT3 signaling within endothelium as a critical antiinflammatory mediator and provide new insight to the protective function of ECs in inflammation.
Journal ArticleDOI
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery.
Akira Moh,Yoshiki Iwamoto,Yoshiki Iwamoto,Gui Xuan Chai,Samual Shao Min Zhang,Arihiro Kano,Derek D. Yang,Derek D. Yang,Wenjun Zhang,Jun Wang,Joerg J. Jacoby,Bin Gao,Richard A. Flavell,Xin-Yuan Fu +13 more
TL;DR: It is shown that STAT3 is required for survival in the acute stage after 70% hepatectomy and plays a role in inflammatory reaction after hepatocyte necrosis, however, the hepatocytic STAT3 may have limited role in liver mass recovery although DNA synthesis may be impaired.