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Gui Xuan Chai
Researcher at Yale University
Publications - 3
Citations - 616
Gui Xuan Chai is an academic researcher from Yale University. The author has contributed to research in topics: Inflammation & STAT3. The author has an hindex of 3, co-authored 3 publications receiving 569 citations.
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Journal ArticleDOI
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
Jörg J. Jacoby,April Kalinowski,M.–G. Liu,M.–G. Liu,Samuel Shao Min Zhang,Qian Gao,Gui Xuan Chai,Lan Ji,Yoshiki Iwamoto,Yoshiki Iwamoto,En Li,Michael Schneider,Kerry S. Russell,Xin-Yuan Fu +13 more
TL;DR: The results indicate the crucial functions of STAT3 in cardiomyocyte resistance to inflammation and other acute injury and in pathogenesis of age-related heart failure.
Journal ArticleDOI
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.
Arihiro Kano,Michael J. Wolfgang,Qian Gao,Joerg J. Jacoby,Gui Xuan Chai,William Hansen,Yoshiki Iwamoto,Yoshiki Iwamoto,Jordan S. Pober,Richard A. Flavell,Xin-Yuan Fu +10 more
TL;DR: It is shown that a soluble activity derived from endothelia and dependent on STAT3 is critical for suppression of interferon γ, and this data define STAT3 signaling within endothelium as a critical antiinflammatory mediator and provide new insight to the protective function of ECs in inflammation.
Journal ArticleDOI
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery.
Akira Moh,Yoshiki Iwamoto,Yoshiki Iwamoto,Gui Xuan Chai,Samual Shao Min Zhang,Arihiro Kano,Derek D. Yang,Derek D. Yang,Wenjun Zhang,Jun Wang,Joerg J. Jacoby,Bin Gao,Richard A. Flavell,Xin-Yuan Fu +13 more
TL;DR: It is shown that STAT3 is required for survival in the acute stage after 70% hepatectomy and plays a role in inflammatory reaction after hepatocyte necrosis, however, the hepatocytic STAT3 may have limited role in liver mass recovery although DNA synthesis may be impaired.