J
John A. Hassell
Researcher at McMaster University
Publications - 133
Citations - 7379
John A. Hassell is an academic researcher from McMaster University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 45, co-authored 133 publications receiving 7013 citations. Previous affiliations of John A. Hassell include University of Arkansas for Medical Sciences & Battelle Memorial Institute.
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Journal ArticleDOI
Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
Donald E. White,Natasza A. Kurpios,Dongmei Zuo,John A. Hassell,Sandra Blaess,Ulrich Mueller,William J. Muller +6 more
TL;DR: Using the Cre/LoxP1 recombination system, it is shown that beta1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells.
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Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
Eleftherios Sachlos,Ruth M. Risueño,Sarah Laronde,Zoya Shapovalova,Jong-Hee Lee,Jennifer Russell,Monika Malig,Jamie D. McNicol,Aline Fiebig-Comyn,Monica Graham,Marilyne Levadoux-Martin,Jung Bok Lee,Andrew O. Giacomelli,John A. Hassell,Daniela Fischer-Russell,Michael Trus,Ronan Foley,Brian Leber,Anargyros Xenocostas,Eric D. Brown,Tony J. Collins,Mickie Bhatia +21 more
TL;DR: It is suggested that dopamine receptors may serve as a biomarker for diverse malignancies, demonstrate the utility of using neoplastic hPSCs for identifying CSC-targeting drugs, and provide support for the use of differentiation as a therapeutic strategy.
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Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.
TL;DR: Findings suggest that PEA3 plays a regulatory role during mouse embryogenesis, and shares extensive sequence similarity with the ETS domain, a conserved protein sequence common to all ets gene family members.
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ERM is required for transcriptional control of the spermatogonial stem cell niche
Chen Chen,Wenjun Ouyang,Vadim Grigura,Qing Zhou,Kay Carnes,Hyunjung Jade Lim,Guang Quan Zhao,Silvia Arber,Silvia Arber,Natasza A. Kurpios,Theresa L. Murphy,Alec M. Cheng,John A. Hassell,Varadaraj Chandrashekar,Marie Claude Hofmann,Rex A. Hess,Kenneth M. Murphy +16 more
TL;DR: It is shown that the Ets related molecule (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal and provides an example of transcriptional control of a vertebrate stem cell niche.
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Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
Nicholas J. Dyson,René Bernards,S H Friend,L R Gooding,John A. Hassell,E O Major,J M Pipas,T Vandyke,Ed Harlow +8 more
TL;DR: All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.