J
John B.J. Kwok
Researcher at University of Sydney
Publications - 198
Citations - 18054
John B.J. Kwok is an academic researcher from University of Sydney. The author has contributed to research in topics: Frontotemporal dementia & Genome-wide association study. The author has an hindex of 51, co-authored 184 publications receiving 15117 citations. Previous affiliations of John B.J. Kwok include Mayo Clinic & University of Cambridge.
Papers
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Journal ArticleDOI
Nonparametric simulation-based statistical analyses for bipolar affective disorder locus on chromosome 21q22.3.
John B.J. Kwok,L. J. Adams,L. J. Adams,Judy A. Salmon,Jennifer A. Donald,Philip B. Mitchell,Peter R. Schofield +6 more
TL;DR: This report provides additional support for the suggestive linkage of a susceptibility locus for BAD on chromosome 21q22.3.
Journal ArticleDOI
Plasma apolipoproteins and physical and cognitive health in very old individuals.
Julia Muenchhoff,Fei Song,Anne Poljak,John D. Crawford,Karen A. Mather,Nicole A. Kochan,Zixuan Yang,Julian N. Trollor,Simone Reppermund,Kate Maston,Adam Theobald,Susanne Kirchner-Adelhardt,John B.J. Kwok,Robyn Richmond,Mark McEvoy,John Attia,Peter W. Schofield,Henry Brodaty,Perminder S. Sachdev +18 more
TL;DR: Levels of some apolipoproteins, especially ApoE, are associated with lifespan and cognitive function in exceptionally long-lived individuals, and sex- and age-related differences were apparent in the association of apoE with cognitive performance.
Journal ArticleDOI
Neural substrates of episodic memory dysfunction in behavioural variant frontotemporal dementia with and without C9ORF72 expansions
Muireann Irish,Emma Devenney,Stephanie Wong,Carol Dobson-Stone,Carol Dobson-Stone,John B.J. Kwok,John B.J. Kwok,Olivier Piguet,Olivier Piguet,Olivier Piguet,John R. Hodges,John R. Hodges,John R. Hodges,Michael Hornberger,Michael Hornberger,Michael Hornberger +15 more
TL;DR: It is demonstrated that while episodic memory is disrupted to the same extent irrespective of genetic predisposition in bvFTD, distinct neural changes specific to each patient group are evident.
Journal ArticleDOI
Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques
Claire E. Shepherd,Claire E. Shepherd,Gillian C. Gregory,Gillian C. Gregory,James C. Vickers,William S. Brooks,William S. Brooks,John B.J. Kwok,Peter R. Schofield,Peter R. Schofield,Jillian J. Kril,Glenda M. Halliday,Glenda M. Halliday +12 more
TL;DR: It is suggested that PS-1 mutations increase tau deposition while mutation-specific cellular responses determine phosphorylation events and may influence cell death mechanisms.
Journal ArticleDOI
Progression in Behavioral Variant Frontotemporal Dementia: A Longitudinal Study.
Emma Devenney,Emma Devenney,Lauren Bartley,Chris Hoon,Claire O'Callaghan,Fiona Kumfor,Fiona Kumfor,Michael Hornberger,Michael Hornberger,John B.J. Kwok,John B.J. Kwok,Glenda M. Halliday,Glenda M. Halliday,Matthew C. Kiernan,Olivier Piguet,Olivier Piguet,John R. Hodges,John R. Hodges +17 more
TL;DR: A continuum of neuropsychological scores, progression rates, and atrophy severity emerged across patients in probable, possible, changed status, and nonchanged status groups; patients with probable BVFTD exhibited the most severe abnormalities.