J
John B.J. Kwok
Researcher at University of Sydney
Publications - 198
Citations - 18054
John B.J. Kwok is an academic researcher from University of Sydney. The author has contributed to research in topics: Frontotemporal dementia & Genome-wide association study. The author has an hindex of 51, co-authored 184 publications receiving 15117 citations. Previous affiliations of John B.J. Kwok include Mayo Clinic & University of Cambridge.
Papers
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Journal ArticleDOI
Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals.
Carl-Johan Boraxbekk,David Ames,Nicole A. Kochan,Teresa Lee,Anbupalam Thalamuthu,Wei Wen,Nicola J. Armstrong,John B.J. Kwok,Peter R. Schofield,Peter R. Schofield,Simone Reppermund,Margaret J. Wright,Julian N. Trollor,Henry Brodaty,Perminder S. Sachdev,Karen A. Mather +15 more
TL;DR: Overall there did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampusal atrophy in two cohorts of older adults.
Journal ArticleDOI
Concordance between direct and imputed APOE genotypes using 1000 genomes data
Christopher Oldmeadow,Elizabeth G. Holliday,Mark McEvoy,Rodney J. Scott,John B.J. Kwok,Karen A. Mather,Perminder S. Sachdev,Peter W. Schofield,John Attia +8 more
TL;DR: There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not included in any of the common microarray platforms, so directly measured APOE genotypes are compared with those imputed using microarray data and the "1000 Genomes" dataset in a sample of 320 Caucasians.
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Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model
Theresa N. T. Dang,Carol Dobson-Stone,Carol Dobson-Stone,Elias N. Glaros,Woojin S. Kim,Woojin S. Kim,Marianne Hallupp,Lauren Bartley,Olivier Piguet,Olivier Piguet,John R. Hodges,John R. Hodges,Glenda M. Halliday,Glenda M. Halliday,Kay L. Double,Kay L. Double,Peter R. Schofield,Peter R. Schofield,Peter J. Crouch,Peter J. Crouch,John B.J. Kwok,John B.J. Kwok +21 more
TL;DR: Clinical, cellular and animal data provide strong evidence that PROG could be a valid therapy for specific related disorders of FTD.
Journal ArticleDOI
Exclusion of linkage between bipolar affective disorder and chromosome 16 in 12 Australian pedigrees.
L. J. Adams,Judy A. Salmon,John B.J. Kwok,Christina Vivero,Jennifer A. Donald,Philip B. Mitchell,Peter R. Schofield +6 more
TL;DR: Results indicate that no linkage exists between BAD and chromosome 16 markers in this group of Australian families, and the 16p13 region was convincingly excluded from linkage to BAD.
Journal ArticleDOI
Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory
Woojin S. Kim,Woojin S. Kim,Woojin S. Kim,YuHong Fu,YuHong Fu,YuHong Fu,Carol Dobson-Stone,Carol Dobson-Stone,Carol Dobson-Stone,Jen-Hsiang T. Hsiao,Jen-Hsiang T. Hsiao,Kani Shang,Kani Shang,Marianne Hallupp,Marianne Hallupp,Marianne Hallupp,Peter R. Schofield,Peter R. Schofield,Brett Garner,Brett Garner,Tim Karl,Tim Karl,John B.J. Kwok,John B.J. Kwok,John B.J. Kwok +24 more
TL;DR: Fluvoxamine has a clear impact on γ-secretase activity and AβPP processing to generate Aβ, and may have a protective effect on cognition in the J20 mice.