J
John B.J. Kwok
Researcher at University of Sydney
Publications - 198
Citations - 18054
John B.J. Kwok is an academic researcher from University of Sydney. The author has contributed to research in topics: Frontotemporal dementia & Genome-wide association study. The author has an hindex of 51, co-authored 184 publications receiving 15117 citations. Previous affiliations of John B.J. Kwok include Mayo Clinic & University of Cambridge.
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Journal ArticleDOI
Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson's Disease Patient Monocytes and Inversely Correlates with Motor Severity.
Laura P. Hughes,Marilia Pereira,Deborah A Hammond,John B.J. Kwok,Glenda M. Halliday,Simon J.G. Lewis,Nicolas Dzamko +6 more
TL;DR: In this paper, the authors measured glucocerebrosidase activity in cryopreserved peripheral blood monocytes from 30 Parkinson's disease patients and 30 matched controls and identified any clinical correlation with disease severity.
Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept
Barbara Franke,Jason L. Stein,Stephan Ripke,Verneri Anttila,Derrek P. Hibar,Kimm J. E. van Hulzen,Alejandro Arias-Vásquez,Jordan W. Smoller,Thomas E. Nichols,Michael C. Neale,Andrew M. McIntosh,Phil Lee,Francis J. McMahon,Andreas Meyer-Lindenberg,Manuel Mattheisen,Ole A. Andreassen,Oliver Gruber,Perminder S. Sachdev,Roberto Roiz-Santiañez,Andrew J. Saykin,Stefan Ehrlich,Karen A. Mather,Jessica A. Turner,Emanuel Schwarz,Anbupalam Thalamuthu,Yin Yao,Yvonne Y.W. Ho,Nicholas G. Martin,Margaret J. Wright,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Brendan Bulik-Sullivan,David A. Collier,Hailiang Huang,Tune H. Pers,Ingrid Agartz,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Murray J. Cairns,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberley D. Chambert,Raymond C.K. Chan,Eric Y.H. Chen,Ronald Y.L. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,Benedicto Crespo-Facorro,James J. Crowley,David Curtis,Michael H. Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Lynn E. DeLisi,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Peter Eichhammer,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert B. Freedman,Nelson B. Freimer,Joseph I. Friedman,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Joel N. Hirschhorn,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,Anna K. Kähler,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,Brian Kelly,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Claudine Laurent,S. Hong Lee,Jimmy Lee Chee Keong,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Jouko Lönnqvist,Carmel M. Loughland,Jan Lubinski,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,Jacques Mallet,Sara Marsal,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Ole Mors,Bertram Müller-Myhsok,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Diana O. Perkins,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian Schubert,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Hon-Cheong So,Erik Söderman,Chris C. A. Spencer,Eli A. Stahl,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Srinivas Thirumalai,Draga Toncheva,Paul A. Tooney,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Jing Qin Wu,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Peter M. Visscher,Rolf Adolfsson,Douglas Blackwood,Anders D. Børglum,Elvira Bramon,Joseph D. Buxbaum,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Anil K. Malhotra,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Nöthen,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Mark J. Daly,Patrick F. Sullivan,Michael Conlon O'Donovan,Miguel E. Rentería,Sylvane Desrivières,Neda Jahanshad,Roberto Toro,Katharina Wittfeld,Lucija Abramovic,Micael Andersson,Benjamin S. Aribisala,Nicola J. Armstrong,Manon Bernard,Marc M. Bohlken,Marco P. Boks,Janita Bralten,Andrew A. Brown,M. Mallar Chakravarty,Qiang Chen,Christopher R.K. Ching,Gabriel Cuellar-Partida,Anouk den Braber,Sudheer Giddaluru,Aaron Goldman,Oliver Grimm,Tulio Guadalupe,Johanna Hass,Girma Woldehawariat,Avram J. Holmes,Martine Hoogman,Deborah Janowitz,Tianye Jia,Sungeun Kim,Marieke Klein,Bernd Kraemer,Loes M. Olde Loohuis,Michelle Luciano,Christine Macare,Yuri Milaneschi,Kwangsik Nho,Martina Papmeyer,Adaikalavan Ramasamy,Shannon L. Risacher,Emma J. Rose,Alireza Salami,Philipp G. Sämann,Lianne Schmaal,Andrew J. Schork,Jean Shin,Lachlan T. Strike,Alexander Teumer,Marjolein M.J. van Donkelaar,Kristel R. van Eijk,Raymond K. Walters,Lars T. Westlye,Christopher D. Whelan,Anderson M. Winkler,Marcel P. Zwiers,Saud Alhusaini,Lavinia Athanasiu,Marina Hakobjan,Cecilie B. Hartberg,Unn K. Haukvik,Angelien Heister,D. Höhn,Dalia Kasperaviciute,David C. Liewald,Lorna M. Lopez,Remco R. R. Makkinje,Mar Matarin,Marlies Naber,David R. McKay,Margaret Needham,Allison C. Nugent,Benno Pütz,Natalie A. Royle,Li Shen,Emma Sprooten,Daniah Trabzuni,Saskia S. L. van der Marel,Esther Walton,Christiane Wolf,Laura Almasy,David Ames,Sampath Arepalli,Amelia A. Assareh,Mark E. Bastin,Henry Brodaty,Kazima B. Bulayeva,Melanie A. Carless,Joanne E. Curran,Michael Czisch,Greig I. de Zubicaray,Allissa Dillman,Ravi Duggirala,Thomas D. Dyer,Susanne Erk,Iryna O. Fedko,Luigi Ferrucci,Tatiana Foroud,Peter T. Fox,Masaki Fukunaga,Raphael Gibbs,Harald H H Göring,Robert C. Green,Sebastian Guelfi,Narelle K. Hansell,Catharina A. Hartman,Katrin Hegenscheid,Andreas Heinz,Dena G. Hernandez,Dirk J. Heslenfeld,Pieter J. Hoekstra,Florian Holsboer,Georg Homuth,Jouke-Jan Hottenga,Clifford R. Jack,Mark Jenkinson,Robert L. Johnson,Ryota Kanai,Maria Keil,Jack W. Kent,Peter Kochunov,John B.J. Kwok,Stephen M. Lawrie,Xinmin Liu,Dan L. Longo,Katie L. McMahon,Eva Meisenzahl,Sebastian Mohnke,Grant W. Montgomery,Jeanette C. Mostert,Thomas W. Mühleisen,Mike A. Nalls,Lars Nilsson,Kazutaka Ohi,Rene L. Olvera,Rocío Pérez-Iglesias,G. Bruce Pike,Steven G. Potkin,Ivar Reinvang,Simone Reppermund,Nina Romanczuk-Seiferth,Glenn D. Rosen,Knut Schnell,Peter R. Schofield,Colin Smith,Vidar M. Steen,Jessika E. Sussmann,Arthur W. Toga,Bryan J. Traynor,Juan C. Troncoso,Maria del C. Valdés Hernández,Dennis van 't Ent,Marcel P. van der Brug,Nic J.A. van der Wee,Marie-José van Tol,Dick J. Veltman,Thomas H. Wassink,Eric Westman,Ronald H. Zielke,Alan B. Zonderman,David G. Ashbrook,Reinmar Hager,Lu Lu,Robert W. Williams,Han G. Brunner,Jan K. Buitelaar,Vince D. Calhoun,Gianpiero L. Cavalleri,Anders M. Dale,Gareth E. Davies,Norman Delanty,Chantal Depondt,Wayne C. Drevets,Thomas Espeseth,Randy L. Gollub,Beng-Choon Ho,Wolfgang Hoffmann,Norbert Hosten,Stephanie LeHellard,Matthias Nauck,Lars Nyberg,Massimo Pandolfo,Brenda W.J.H. Penninx,Sanjay M. Sisodiya,Hans van Bokhoven,Neeltje E.M. van Haren,Henry Völzke,Henrik Walter,Michael W. Weiner,Wei Wen,Tonya White,John Blangero,Dorret I. Boomsma,Rachel M. Brouwer,Dara M. Cannon,Mark R. Cookson,Eco J. C. de Geus,Ian J. Deary,Guillén Fernández,Simon E. Fisher,Clyde Francks,David C. Glahn,Hans J. Grabe,John Hardy,Ryota Hashimoto,Hilleke E. Hulshoff Pol,Iwona Kłoszewska,Simon Lovestone,Venkata S. Mattay,Patrizia Mecocci,Tomáš Paus,Zdenka Pausova,Mina Ryten,Andrew Simmons,Andrew B. Singleton,Hilkka Soininen,Joanna M. Wardlaw,Michael E. Weale,Hieab H.H. Adams,Lenore J. Launer,Stephan Seiler,Reinhold E. Schmidt,Ganesh Chauhan,Claudia L. Satizabal,James T. Becker,Lisa R. Yanek,Sven J. van der Lee,Maritza Ebling,Bruce Fischl,W. T. Longstreth,Douglas N. Greve,Helena Schmidt,Paul A. Nyquist,Louis N. Vinke,Cornelia M. van Duijn,Xue Luting,Bernard Mazoyer,Joshua C. Bis,Vilmundur Gudnason,Sudha Seshadri,M. Arfan Ikram,Gunter Schumann,Paul M. Thompson,Sarah E. Medland +562 more
TL;DR: In this article, the authors integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects).
Posted ContentDOI
Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan
Rachel M. Brouwer,Rachel M. Brouwer,Marieke Klein,Katrina L. Grasby,Hugo G. Schnack,Neda Jahanshad,Jalmar Teeuw,Sophia I. Thomopoulos,Emma Sprooten,Carol E. Franz,Nitin Gogtay,William S. Kremen,Matthew S. Panizzon,Loes M. Olde Loohuis,Christopher D. Whelan,Moji Aghajani,Clara Alloza,Dag Alnæs,Dag Alnæs,Eric Artiges,Rosa Ayesa-Arriola,Gareth J. Barker,Mark E. Bastin,Elisabet Blok,Erlend Bøen,Isabella A. Breukelaar,Joanna Bright,Elizabeth E.L. Buimer,Robin Bülow,Dara M. Cannon,Simone Ciufolini,Nicolas Crossley,Nicolas Crossley,Christienne G. Damatac,Paola Dazzan,Casper L. de Mol,Sonja M C de Zwarte,Sylvane Desrivières,Covadonga M. Díaz-Caneja,Nhat Trung Doan,Katharina Dohm,Juliane H. Fröhner,Janik Goltermann,Antoine Grigis,Dominik Grotegerd,Laura K.M. Han,Mathew A. Harris,Catharina A. Hartman,Sarah J. Heany,Walter Heindel,Dirk J. Heslenfeld,Sarah Hohmann,Bernd Ittermann,Philip R. Jansen,Philip R. Jansen,Joost Janssen,Tianye Jia,Tianye Jia,Jiyang Jiang,Christiane Jockwitz,Christiane Jockwitz,Temmuz Karali,Daniel Keeser,Martijn G.J.C. Koevoets,Rhoshel K. Lenroot,Rhoshel K. Lenroot,Rhoshel K. Lenroot,Berend Malchow,René C.W. Mandl,Vicente Medel,Susanne Meinert,Catherine Morgan,Thomas W. Mühleisen,Thomas W. Mühleisen,Thomas W. Mühleisen,Leila Nabulsi,Nils Opel,Victor Ortiz-García de la Foz,Bronwyn Overs,Marie-Laure Paillère Martinot,Erin Burke Quinlan,Ronny Redlich,Tiago Reis Marques,Tiago Reis Marques,Jonathan Repple,Gloria Roberts,Gennady V. Roshchupkin,Nikita Setiaman,Nikita Setiaman,Elena Shumskaya,Frederike Stein,Gustavo Sudre,Shun Takahashi,Anbupalam Thalamuthu,Diana Tordesillas-Gutiérrez,Aad van der Lugt,Neeltje E.M. van Haren,Neeltje E.M. van Haren,Joanna M. Wardlaw,Wei Wen,Henk-Jan Westeneng,Katharina Wittfeld,Katharina Wittfeld,Alyssa H. Zhu,André Zugman,André Zugman,Nicola J. Armstrong,Gaia Bonfiglio,Janita Bralten,Shareefa Dalvie,Gail Davies,Marta Di Forti,Linda Ding,Gary Donohoe,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Javier González-Peñas,João P.O.F.T. Guimarães,Georg Homuth,Jouke-Jan Hottenga,Maria J. Knol,John B.J. Kwok,John B.J. Kwok,Stephanie Le Hellard,Stephanie Le Hellard,Karen A. Mather,Karen A. Mather,Yuri Milaneschi,Derek W. Morris,Markus M. Nöthen,Sergi Papiol,Marcella Rietschel,Marcos L. Santoro,Marcos L. Santoro,Vidar M. Steen,Vidar M. Steen,Jason L. Stein,Fabian Streit,Rick M. Tankard,Alexander Teumer,Dennis van 't Ent,Dennis van der Meer,Dennis van der Meer,Dennis van der Meer,Kristel R. van Eijk,Evangelos Vassos,Javier Vázquez-Bourgon,Stephanie H. Witt,Alzheimer’s Disease Neuroimaging Initiative,Hieab H.H. Adams,Ingrid Agartz,Ingrid Agartz,David Ames,Katrin Amunts,Katrin Amunts,Ole A. Andreassen,Ole A. Andreassen,Celso Arango,Tobias Banaschewski,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune,Sintia Iole Belangero,Sintia Iole Belangero,Arun L.W. Bokde,Dorret I. Boomsma,Rodrigo A. Bressan,Rodrigo A. Bressan,Henry Brodaty,Jan K. Buitelaar,Wiepke Cahn,Svenja Caspers,Svenja Caspers,Sven Cichon,Sven Cichon,Sven Cichon,Benedicto Crespo Facorro,Simon R. Cox,Udo Dannlowski,Torbjørn Elvsåshagen,Torbjørn Elvsåshagen,Thomas Espeseth,Thomas Espeseth,Peter Falkai,Simon E. Fisher,Simon E. Fisher,Herta Flor,Janice M. Fullerton,Janice M. Fullerton,Hugh Garavan,Penny A. Gowland,Hans J. Grabe,Hans J. Grabe,Tim Hahn,Andreas Heinz,Manon H.J. Hillegers,Manon H.J. Hillegers,Jacqueline Hoare,Pieter J. Hoekstra,Mohammad Arfan Ikram,Andrea Parolin Jackowski,Andrea Parolin Jackowski,Andreas Jansen,Erik G. Jönsson,Erik G. Jönsson,René S. Kahn,René S. Kahn,Tilo Kircher,Mayuresh S. Korgaonkar,Axel Krug,Axel Krug,Herve Lemaitre,Ulrik Fredrik Malt,Jean-Luc Martinot,Colm McDonald,Philip B. Mitchell,Philip B. Mitchell,Ryan L. Muetzel,Robin M. Murray,Frauke Nees,Frauke Nees,Igor Nenadic,Jaap Oosterlaan,Roel A. Ophoff,Roel A. Ophoff,Pedro Mario Pan,Pedro Mario Pan,Brenda W.J.H. Penninx,Luise Poustka,Perminder S. Sachdev,Giovanni Abrahão Salum,Giovanni Abrahão Salum,Peter R. Schofield,Peter R. Schofield,Gunter Schumann,Gunter Schumann,Gunter Schumann,Philip Shaw,Kang Sim,Michael N. Smolka,Dan J. Stein,Julian N. Trollor,Leonard H. van den Berg,Jan H. Veldink,Henrik Walter,Lars T. Westlye,Lars T. Westlye,Robert Whelan,Tonya White,Tonya White,Margaret J. Wright,Sarah E. Medland,Barbara Franke,Paul M. Thompson,Hilleke E. Hulshoff Pol +255 more
TL;DR: In this article, the authors identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan.
Journal ArticleDOI
Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-dideazafolic acid cytotoxicity by 5,10-dideazatetrahydrofolate in L1210 cells with decrease in DNA fragmentation and deoxyadenosine triphosphate pools.
TL;DR: The hypothesis that inhibitory effects on de novo purine biosynthesis by inhibitors of dihydrofolate reductase may limit cytotoxicity is supported, and results indicate that a rise in dATP pools may be an important cytotoxic signal.
Journal ArticleDOI
Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer’s disease
Kirsten Coupland,Woojin S. Kim,Glenda M. Halliday,Marianne Hallupp,Carol Dobson-Stone,John B.J. Kwok +5 more
TL;DR: A novel effect of PSEN1 on MAPT methylation is indicated, and a mutation-specific effect of the PSen1 Δex9 mutation is suggested, suggesting a decreased ability to modulate endogenous MAPT gene methylation.