J
John C. S. Harding
Researcher at University of Saskatchewan
Publications - 145
Citations - 4461
John C. S. Harding is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Fetus. The author has an hindex of 30, co-authored 143 publications receiving 3907 citations. Previous affiliations of John C. S. Harding include Washington University in St. Louis & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection.
Carolina M. Malgarin,Fiona Moser,J. Alex Pasternak,J. Alex Pasternak,Glenn Hamonic,Susan E. Detmer,Daniel J. MacPhee,John C. S. Harding +7 more
TL;DR: In this paper, the authors performed two experiments examining hypoxia and apoptosis in PRRSV-infected and noninfected, third-trimester fetuses to elucidate possible associations with fetal death.
Journal ArticleDOI
Transcriptomic and Epigenetic Profiling of the Lung of Influenza-Infected Pigs: A Comparison of Different Birth Weight and Susceptibility Groups
Jamie M. Wilkinson,Rayna E. Gunvaldsen,Susan E. Detmer,Michael K. Dyck,Walter T. Dixon,George R. Foxcroft,Graham Plastow,John C. S. Harding +7 more
TL;DR: This study found no evidence that the transcriptional immune response to influenza was adversely affected by low litter birth weight, but did identify several candidate genes for driving disease pathology.
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Effect of a genetic marker for the GBP5 gene on resilience to a polymicrobial natural disease challenge in pigs
Ryan L Jeon,Jian Cheng,Austin M. Putz,Qian Dong,John C. S. Harding,Michael K. Dyck,Graham Plastow,Frederic Fortin,Joan K. Lunney,Raymond R. R. Rowland,Pig Gen Canada,Jack C. M. Dekkers +11 more
TL;DR: Results from the natural disease challenge indicated that the favorable allele for the WUR SNP was significantly associated with greater average daily gain and with lower numbers of treatments in the challenge nursery and across the nursery and finisher, although its linkage disequilibrium with the putative causative mutation in the GBP5 gene must continue to be monitored.
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Network analyses using case-control data to describe and characterize the initial 2014 incursion of porcine epidemic diarrhea (PED) in Canadian swine herds.
TL;DR: Network descriptive measures, as well as the results of the hypotheses testing indicate little significance in the roles of animal movement, animal transportation companies, and semen suppliers during the initial phase of the 2014 Canadian PED outbreak.
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Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds.
Leticia P Sanglard,PigGen Canada,Benny E. Mote,Philip Willson,John C. S. Harding,Graham Plastow,Jack C. M. Dekkers,Nick V. L. Serão +7 more
TL;DR: The genetic basis of antibody (Ab) response to common infectious pathogens in health-challenged commercial swine herds as potential indicator traits for disease resilience and genetic selection of Ab response in commercial sows is suggested, but with variable success depending on the trait and the time-point of collection.