J
John C. S. Harding
Researcher at University of Saskatchewan
Publications - 145
Citations - 4461
John C. S. Harding is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Fetus. The author has an hindex of 30, co-authored 143 publications receiving 3907 citations. Previous affiliations of John C. S. Harding include Washington University in St. Louis & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
Fetal cytokine response to porcine reproductive and respiratory syndrome virus-2 infection.
TL;DR: Results show near complete compartmentalization of the fetal immune response to infected fetuses and suggest this immune response is not a major contributor to fetal death.
Additional file 5: of Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Jamie Wilkinson,Hua Bao,Andrea Ladinig,Linjun Hong,Paul Stothard,Joan K Lunney,Graham Plastow,John C. S. Harding +7 more
Journal ArticleDOI
Classification of fetal resilience to porcine reproductive and respiratory syndrome (PRRS) based on temporal viral load in late gestation maternal tissues and fetuses
Carolina M. Malgarin,Roman Nosach,Predrag Novakovic,Muhammad Suleman,Andrea Ladinig,Susan E. Detmer,Daniel J. MacPhee,John C. S. Harding +7 more
TL;DR: The random forest model identified that 'viral load in fetal thymus' and duration of infection ('DPI') as the most important factors predicting fetal resilience and resistance and IUGR fetuses had lower viral load and were less frequently compromised or dead compared to non-IUGR and average cohorts.
Journal Article
Antimicrobial use through feed, water, and injection in 20 swine farms in Alberta and Saskatchewan
Leigh B. Rosengren,Cheryl L. Waldner,Richard J. Reid-Smith,John C. S. Harding,Sheryl P. Gow,Wendy Wilkins +5 more
TL;DR: Existing on-farm data would be a valuable resource for investigating AMU and AMR in pigs because antimicrobial exposures in feed and water were markedly more common than through injection.
Journal ArticleDOI
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T cell leukemia
Mathew Cherian,Sydney L. Olson,Hemalatha Sundaramoorthi,Kitra Cates,Xiaogang Cheng,John C. S. Harding,Andrew Martens,Grant A. Challen,Manoj Tyagi,Lee Ratner,Daniel Rauch +10 more
TL;DR: High-throughput whole-exome sequencing revealed recurrent activating genetic alterations in the T-cell receptor, CD28, and NF-κB pathways and found that IRF4, which is transcriptionally activated downstream of these pathways, is frequently mutated in ATL.