J
John C. S. Harding
Researcher at University of Saskatchewan
Publications - 145
Citations - 4461
John C. S. Harding is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Fetus. The author has an hindex of 30, co-authored 143 publications receiving 3907 citations. Previous affiliations of John C. S. Harding include Washington University in St. Louis & University of Veterinary Medicine Vienna.
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IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity
TL;DR: Findings identify IL-15 and IL-1α as therapeutic targets in lymphoma after developing the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time.
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HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice
Alison K. Esser,Daniel Rauch,Jingyu Xiang,John C. S. Harding,Nicole A. Kohart,Michael H. Ross,Xinming Su,Kevin Wu,Devra Huey,Yalin Xu,Kiran Vij,Patrick L. Green,Thomas J. Rosol,Stefan Niewiesk,Lee Ratner,Katherine N. Weilbaecher +15 more
TL;DR: It is demonstrated that Gzmb-HBZ mice model ATL bone disease and express factors that are current therapeutic targets for metastatic and bone resident tumors.
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HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia
Jingyu Xiang,Daniel Rauch,Devra Huey,Amanda R. Panfil,Xiaogang Cheng,Alison K. Esser,Xinming Su,John C. S. Harding,Yalin Xu,Gregory C. Fox,Francesca Fontana,Takayuki Kobayashi,Junyi Su,Hemalatha Sundaramoorthi,Wing Hing Wong,Yizhen Jia,Thomas J. Rosol,Thomas J. Rosol,Deborah J. Veis,Patrick L. Green,Stefan Niewiesk,Lee Ratner,Katherine N. Weilbaecher +22 more
TL;DR: The critical role of HBZ is shown in driving ATL-associated bone loss through RANKL and denosumab is identified as a potential treatment to prevent bone complications in ATL patients.
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Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks.
Francesca Bertolini,John C. S. Harding,Benny E. Mote,Andrea Ladinig,Graham Plastow,Max F. Rothschild +5 more
TL;DR: First genomic picture of PEDV resilience in suckling piglets is provided, consisting of 152 genes included in one or more Gene Ontology terms that can be related to PED development, as well as mechanisms generally linked to resilience or diarrhea development.
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Transcriptomic analysis identifies candidate genes and functional networks controlling the response of porcine peripheral blood mononuclear cells to mitogenic stimulation.
Jamie M. Wilkinson,Michael K. Dyck,Walter T. Dixon,G R Foxcroft,S. Dhakal,John C. S. Harding +5 more
TL;DR: Overall, the gene expression profile of the Con A-stimulated porcine PBMC points to a Th(1) bias in immune activation, and further work is required to determine whether polymorphisms linked to genes identified in this study affect this immune response trait in pig populations and whether the trait itself correlates with decreased susceptibility to intracellular pathogens in swine.