J
John C. S. Harding
Researcher at University of Saskatchewan
Publications - 145
Citations - 4461
John C. S. Harding is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Fetus. The author has an hindex of 30, co-authored 143 publications receiving 3907 citations. Previous affiliations of John C. S. Harding include Washington University in St. Louis & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
Reproduction of Mucohaemorrhagic Diarrhea and Colitis Indistinguishable from Swine Dysentery following Experimental Inoculation with “Brachyspira hampsonii” Strain 30446
Joseph E. Rubin,Matheus O. Costa,Janet E. Hill,Heather E. Kittrell,Champika Fernando,Yanyun Huang,Brendan O'Connor,John C. S. Harding +7 more
TL;DR: “Brachyspira hampsonii” strain 30446 causes mucohaemorrhagic diarrhea in pigs following a 4–9 day incubation period, and culture and 30446-specific qPCR are reliable methods of detection of this organism in feces and tissues of diarrheic pigs.
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Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade
Daniel Rauch,Kevin C. Conlon,Murali Janakiram,Jonathan E. Brammer,John C. S. Harding,B. Hilda Ye,Xingxing Zang,Xiaoxin Ren,Sydney L. Olson,Xiaogang Cheng,Milos D. Miljkovic,Hemalatha Sundaramoorthi,Ancy Joseph,Zachary L. Skidmore,Obi L. Griffith,Malachi Griffith,Thomas A. Waldmann,Lee Ratner +17 more
TL;DR: It is demonstrated that the PD-1 inhibitor, nivolumab, led to rapid progression in patients with adult T-cell leukemia/lymphoma (ATLL)(NCT02631746), and a previously unappreciated origin of these malignant cells was revealed, and a novel connection between ATLL cells and tumor-resident Tregs was identified.
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HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
Ling Gao,Hongju Deng,Haibo Zhao,Angela C. Hirbe,John C. S. Harding,Lee Ratner,Katherine N. Weilbaecher +6 more
TL;DR: Tax+ mice represent the first animal model of high-penetrance spontaneous osteolytic bone metastasis and underscore the critical role of nonmalignant host cells recruited by tumor cells in the process of cancer progression and metastasis.
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Nested polymerase chain reaction detection and duration of porcine circovirus type 2 in semen with sperm morphological analysis from naturally infected boars.
TL;DR: PCV2 DNA in semen does not appear to have detrimental effects on sperm morphology; however, boar age and, possibly, breed may contribute to the persistence of PCV2-shedding in semen.
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Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd
Nick V. L. Serão,Oswald Matika,Robert Kemp,John C. S. Harding,Stephen Bishop,Graham Plastow,Jack C. M. Dekkers +6 more
TL;DR: The results indicate a significant genomic component associated with PRRSV antibody response and NSB in this data set, and the high heritability and genetic correlation estimates for S/P ratio during the PRRS phase suggest that S/p ratio could be used as an indicator of the impact of PRRS on reproductive traits.