J
John C. S. Harding
Researcher at University of Saskatchewan
Publications - 145
Citations - 4461
John C. S. Harding is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Fetus. The author has an hindex of 30, co-authored 143 publications receiving 3907 citations. Previous affiliations of John C. S. Harding include Washington University in St. Louis & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T-cell leukemia lymphoma.
Lee Ratner,Daniel Rauch,H Abel,Breanna Caruso,Ariela Noy,Stefan K. Barta,Samir Parekh,Juan Carlos Ramos,Richard F. Ambinder,Adrienne A. Phillips,John C. S. Harding,Hicham H. Baydoun,Xiaogang Cheng,Steve Jacobson +13 more
TL;DR: Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T- cell leukemia lymphoma
Journal ArticleDOI
Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Jamie M. Wilkinson,Hua Bao,Andrea Ladinig,Andrea Ladinig,Linjun Hong,Linjun Hong,Paul Stothard,Joan K. Lunney,Graham Plastow,John C. S. Harding +9 more
TL;DR: In this article, RNA-sequencing of two sites, uterine endothelium with adherent placental tissue and fetal thymus, was performed 21 days post-challenge on four groups of fetuses selected from a large PRRSV challenge experiment of pregnant gilts: control (CON), uninfected (UNINF), infected (INF) and meconium-stained (MEC) (n = 12/group).
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Birth Weight, Intrauterine Growth Retardation and Fetal Susceptibility to Porcine Reproductive and Respiratory Syndrome Virus
Andrea Ladinig,George R. Foxcroft,Carolyn Ashley,Joan K. Lunney,Graham Plastow,John C. S. Harding +5 more
TL;DR: This study clearly demonstrates that birth weight is a transgenerational trait in pigs, and provides evidence that larger fetuses are more susceptible to transplacental PRRSv infection.
Journal ArticleDOI
Genetic analysis of disease resilience in wean-to-finish pigs from a natural disease challenge model
Jian Cheng,Austin M. Putz,John C. S. Harding,Michael K. Dyck,Frederic Fortin,Graham Plastow,PigGen Canada,Jack C. M. Dekkers +7 more
TL;DR: Performance and resilience traits under a polymicrobial disease challenge are heritable and can be changed by selection, and Phenotypes extracted from feed intake patterns can be used as genetic indicator traits for disease resilience.
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Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts.
TL;DR: An important role of apoptosis is suggested in the pathogenesis of uterine epithelial and trophoblastic cell death at the MFI, which is significantly associated with fetal demise during in utero type 2 PRRSV infection.