J
John C. S. Harding
Researcher at University of Saskatchewan
Publications - 145
Citations - 4461
John C. S. Harding is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Fetus. The author has an hindex of 30, co-authored 143 publications receiving 3907 citations. Previous affiliations of John C. S. Harding include Washington University in St. Louis & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma.
TL;DR: Insight is provided into a possible mechanism by which IFN-gamma contributes to host resistance against HTLV-induced tumors through an angiostatic effect.
Journal ArticleDOI
Development and validation of a SYBR green real-time PCR for the quantification of porcine circovirus type 2 in serum, buffy coat, feces, and multiple tissues.
Kathleen A. McIntosh,Anju Tumber,John C. S. Harding,Steven Krakowka,John A. Ellis,Janet E. Hill +5 more
TL;DR: A novel real-time polymerase chain reaction (PCR) assay targeting the highly conserved rep gene (ORF1) was developed with a conserved target sequence, and performed efficiently in quantification of PCV2 in a variety of tissues from naturally and experimentally infected pigs.
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Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants
TL;DR: Investigation of the effects of PS-341, a peptide boronate inhibitor of the proteasome in HTLV-1 Tax transgenic tumors in vitro and in vivo revealed heterogeneity in drug responsiveness, but transplanted Tax tumors in Rag-1 mice showed consistent inhibition of tumor growth and prolonged survival in response to the same drug regimen.
Journal ArticleDOI
Variation in Fetal Outcome, Viral Load and ORF5 Sequence Mutations in a Large Scale Study of Phenotypic Responses to Late Gestation Exposure to Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Andrea Ladinig,Jamie Wilkinson,Carolyn Ashley,Susan E. Detmer,Joan K. Lunney,Graham Plastow,John C. S. Harding +6 more
TL;DR: Viral load in fetal thymus and in fetal serum was positively associated with viral load in endometrium, suggesting the virus exploits dynamic linkages between individual maternal-fetal compartments and indicates it is an early pathological condition of reproductive PRRS.
Journal Article
Hematology and biochemistry reference intervals for Ontario commercial nursing pigs close to the time of weaning.
TL;DR: This article provided reference intervals for pig hematology and biochemistry parameters of 3-week-old commercial nursing piglets in Ontario, and the 95% reference interval, mean, median, range, and 90% confidence intervals were calculated for each parameter.