J
John G. Aunins
Researcher at Merck & Co.
Publications - 74
Citations - 5233
John G. Aunins is an academic researcher from Merck & Co.. The author has contributed to research in topics: Cell culture & Microbiome. The author has an hindex of 26, co-authored 69 publications receiving 4882 citations. Previous affiliations of John G. Aunins include University of Minnesota & Universidade Nova de Lisboa.
Papers
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Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal ArticleDOI
A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection
Sahil Khanna,Darrell S. Pardi,Colleen R. Kelly,Colleen S. Kraft,Tanvi Dhere,Matthew R. Henn,Mary Jane Lombardo,Marin Vulić,Toshiro K. Ohsumi,Jonathan Winkler,Christina Pindar,Barbara H. McGovern,Roger J. Pomerantz,John G. Aunins,David N. Cook,Elizabeth L. Hohmann +15 more
TL;DR: Gut microbiota rapidly diversified, with durable engraftment of spores and no outgrowth of non-spore-forming bacteria found after SER-109 treatment, supporting a novel microbiome-based intervention as a potential therapy for recurrent CDI.
Patent
Synergistic bacterial compositions and methods of production and use thereof
Matthew R. Henn,Geoffrey von Maltzahn,Anthony D'Onofrio,Kevin Litcofsky,David Arthur Berry,David N. Cook,Noubar B. Afeyan,John G. Aunins +7 more
TL;DR: In this paper, therapeutic compositions containing Ecobiotic populations for prevention, treatment and reduction of symptoms associated with dysbiosis of a mammalian subject such as a human were provided, and the compositions were evaluated.
Journal ArticleDOI
Large-scale mammalian cell culture
TL;DR: This work states that through molecular genetic manipulation, cells are more readily cultivated in a medium free of animal proteins, and the need to implement a control policy for fed-batch and perfusion cultures has prompted increased efforts in process monitoring and control.
Journal ArticleDOI
Fed-batch culture of recombinant NS0 myeloma cells with high monoclonal antibody production
TL;DR: Close relationships among nutrient depletion, cell metabolism transition, and cell death are suggested in an amplified NS0 cell line cultivated in a fed-batch culture.