Journal ArticleDOI
Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth
Jonathan R. Keller,Stephen H. Bartelmez,Ewa Sitnicka,Francis W. Ruscetti,Mariaestella Ortiz,John Gooya,Sten Eirik W. Jacobsen +6 more
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TLDR
MIP-1 alpha and TGF beta are direct bidirectional regulators of HPC growth, whose effects are dependent on other growth factors present as well as the maturational state of the HPC assayed.About:
This article is published in Blood.The article was published on 1994-10-01. It has received 88 citations till now. The article focuses on the topics: Transforming growth factor, beta 3 & TGF alpha.read more
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Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
Marion C. Dickson,Julie S. Martin,Frances M. Cousins,Ashok B. Kulkarni,Stefan Karlsson,Rosemary J. Akhurst +5 more
TL;DR: The data indicate that the primary effect of loss of TGF beta 1 function in vivo is not increased haematopoietic or endothelial cell proliferation, which might have been expected by deletion of a negative growth regulator, but defective haem atopoiesis and endothelial differentiation.
Journal Article
EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That Is Up-Regulated upon Maturation
TL;DR: The chemokine receptor, EBI1/CCR7, is strikingly up-regulated upon maturation in three distinct culture systems: 1) mouse bone marrow- derived DC, 2) mouse epidermal Langerhans cells, and 3) human monocyte-derived DC.
Journal ArticleDOI
Chemokine receptor expression by human intestinal epithelial cells.
TL;DR: Human colonocytes have the potential to serve as targets for chemokine signaling, and CXCR4 and CCR5 had a predominant apical and, to a lesser extent, basolateral distribution on human enterocytes, as demonstrated by immunostaining of human colon.
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The role of MIP-1 alpha in inflammation and hematopoiesis.
TL;DR: It is demonstrated that MIP‐1α is required for a normal inflammatory response to influenza virus and are resistant to coxsackievirus‐induced myocarditis, and agents that inhibit the action of MIP-1α may prove useful for controlling inflammation in these and other settings.
Journal ArticleDOI
Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients
Francesco Bertolini,Manuela Battaglia,Paolo Pedrazzoli,Gian Antonio Da Prada,A. Lanza,Davide Soligo,Lorenza Caneva,Barbara Sarina,Scott Murphy,Terry E. Thomas,Gioacchino Robustelli della Cuna +10 more
TL;DR: MP can be expanded ex vivo and safely administered to autologous transplant recipients and further clinical trials will indicate the reinfusion schedule able to consistently abrogate the need for allogeneic platelet transfusion support in autOLOGous transplantation.
References
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Journal ArticleDOI
Purification and Characterization of Mouse Hematopoietic Stem Cells
TL;DR: Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers and thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
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Identification and characterization of an inhibitor of haemopoietic stem cell proliferation.
G J Graham,Eric G. Wright,R Hewick,S D Wolpe,N Wilkie,Debra D. Donaldson,S Lorimore,I B Pragnell +7 more
TL;DR: The biological activities of SCI suggest that it is a primary negative regulator of stem cell proliferation and that it has important therapeutic appli-cations in protecting haemopoietic stem cells from damage during cytotoxic therapies for cancer.
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Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators.
Journal Article
In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection
TL;DR: Using this system, the enrichment of LTRC in the lowest Rh-123 compartment of the sequentially Hö/Rh-123 selected cells appears to be the greatest demonstrated thus far, and further supports previous ones that identify a compartment of L TRC that are largely distinct from CFU-S-12.
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Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells
Hal E. Broxmeyer,B Sherry,Li Lu,Scott Cooper,Kwi-Ok Oh,Patricia Tekamp-Olson,Byoung S. Kwon,A. Cerami +7 more
TL;DR: These results, along with previous studies, suggest that MIP-1 alpha, -1 beta, and -2 may have direct myelopoietic enhancing activity for mature progenitors, while MIP -1 alpha may havedirect suppressing activity for more immature progenitor.