https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

/pdf/aryl-aryl-bond-formation-one-century-after-the-discovery-of-1jdyxlkwix.pdf

Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.

Perp. punya vol. X. Flowering plant, eudicots : sapindales, cucurbitales, myrtaceae. Perp.punya: 1eks.

The Families And Genera Of Vascular Plants

In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chemical synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon-carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this Review, highlights of a number of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.

Palladium-catalyzed cross-coupling reactions in total synthesis.

The US National Cancer Institute (NCI) 60 human tumour cell line anticancer drug screen (NCI60) was developed in the late 1980s as an in vitro drug-discovery tool intended to supplant the use of transplantable animal tumours in anticancer drug screening. This screening model was rapidly recognized as a rich source of information about the mechanisms of growth inhibition and tumour-cell kill. Recently, its role has changed to that of a service screen supporting the cancer research community. Here I review the development, use and productivity of the screen, highlighting several outcomes that have contributed to advances in cancer chemotherapy.

The NCI60 human tumour cell line anticancer drug screen

Bioassay-guided fractionation of the cytotoxic organic extracts of the wood of Thevetia ahouia (Apocyanaceae) led to the isolation of three cardenolide glycosides, neriifolin, 3′-O-methylevomonoside and 2′-acetyl-neriifolin [1–3]. These agents exhibited a distinctive pattern of differential cytotoxicity in the National Cancer Institute's human disease-oriented 60-cell line tumour screening panel, which suggests that follow-up in vivo xenograft evaluations may be warranted. These patterns may be useful in future dereplication studies of extracts potentially containing this class of compound.

The differential cytotoxicity of cardenolides from Thevetia ahouia

Antiviral compositions useful for inhibition of the cytopathic effects of the human immunodeficiency virus (HIV), which is implicated as a causative agent of AIDS (Acquired Immune Deficiency Syndrome), include a new class of HIV-inhibitory compounds, the sulfonic acid-containing glycolipids The pure compounds were active against HIV in cultured human lymphoblastoid CEM, MT-2, LVD-7 and C3-44 cell lines as indicated by the tetrazolium assay, as well as by correlative p24 viral protein and syncytia formation assays

Antiviral compositions containing sulfoquinovosyl glycerol derivatives and analogs thereof and methods for using the same

During the reisolation of the trimeric naphthoquinone derivative conocurvone [1] from an extract of the Australian shrub Conospermum incurvum, six monomeric naphthoquinones were isolated. These include three novel 1,4-naphthoquinone derivatives: 3-methyl-14,15-dihydro-15-hydroxyteretifolione B [3], 3-methyl-14,15-dihydro-15-hydroxyteretifolione B methyl ether [4], and 2,3-dimethyl-6-hydroxy-7-methoxy-1,4-naphthoquinone [5]. In addition, the previously reported compounds 3-methylteretifolione B [6], 3-methylteretifolione B methyl ether [7], and 8-geranyl-2,7-dihydroxy-3-methyl-1,4-naphthoquinone [8] were isolated and identified. The structures of the novel 1,4-naphthoquinones were elucidated by spectral methods. While conocurvone [1] is a potent inhibitor of HIV-1-induced cell killing, all of the monomeric naphthoquinone derivatives were inactive against HIV-1.

Novel naphthoquinones from Conospermum incurvum.

Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified Four new triterpene esters were elucidated; two [3,4] were found in M africana, while three [4,6,7] were found in M membranacea Nmr assignments have also been made for two previously known compounds [2,5] in this group

A reinvestigation of Maprounea triterpenes.

https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2898%2900736-4

John H. Cardellina

Papers

The differential cytotoxicity of cardenolides from Thevetia ahouia

Antiviral compositions containing sulfoquinovosyl glycerol derivatives and analogs thereof and methods for using the same

Novel naphthoquinones from Conospermum incurvum.

A reinvestigation of Maprounea triterpenes.

Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp.