https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

/pdf/aryl-aryl-bond-formation-one-century-after-the-discovery-of-1jdyxlkwix.pdf

Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.

Perp. punya vol. X. Flowering plant, eudicots : sapindales, cucurbitales, myrtaceae. Perp.punya: 1eks.

The Families And Genera Of Vascular Plants

In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chemical synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon-carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this Review, highlights of a number of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.

Palladium-catalyzed cross-coupling reactions in total synthesis.

The US National Cancer Institute (NCI) 60 human tumour cell line anticancer drug screen (NCI60) was developed in the late 1980s as an in vitro drug-discovery tool intended to supplant the use of transplantable animal tumours in anticancer drug screening. This screening model was rapidly recognized as a rich source of information about the mechanisms of growth inhibition and tumour-cell kill. Recently, its role has changed to that of a service screen supporting the cancer research community. Here I review the development, use and productivity of the screen, highlighting several outcomes that have contributed to advances in cancer chemotherapy.

The NCI60 human tumour cell line anticancer drug screen

Novel macrolides, lobatamides A-F (1-6), have been isolated from shallow water Australian collections of Aplidium lobatum, from a deep water collection of Aplidium sp., and from an unidentified Philippine ascidian. Full details of the isolation and structure elucidation of 1-6 are provided herein, along with results and analyses of the testing of lobatamides A-D (1-4) in the NCI human tumor 60 cell-line screen. The lobatamides share a common core structure with the recently described salicylihalamides, which were isolated from a Haliclona sp. sponge. COMPARE analyses of the mean-graph differential cytotoxicity profiles of the lobatamides and the salicylihalamides showed high correlations with each other but not with members of the NCI's standard agents database. These compounds, therefore, appear to comprise a new mechanistic class, meriting further antitumor investigations.

The Lobatamides, Novel Cytotoxic Macrolides from Southwestern Pacific Tunicates.

Emmottene, from the Gorgonian Briareum polyanthes, Contains the First Naturally Occurring trans-Bicyclo(5.1.0)octane

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 47 Screening Models .............................................. 48 Cancer. . . . . . . . . . . . . . . . . . . . . . . .. . . . . .. . . . .. . . . . . . . . . . . . . .. 48 HIV ..................................................... 49 Dereplication of "Nuisance Compounds" ........................... 52 HI V-Inhibitory Plant Metabolites .................................. 54 Buchenavia Alkaloids ....................................... 54 Prostratin ................................................. 55 Phorbol Ester Distribution Studies ............................. 56 Maprounea . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 57 Antitumor Plant Metabolites. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 58 Compounds Affecting Tubulin ................................ 58 Centaureidin .............................................. 58 Flavone SAR .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 59 Chalcones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 59 Renal Selective Saponins from Legumes .. . . . . . . . . . . . . . . . . . . . . .. 60 Conclusions .............................................. . . . .. 62

Chapter Three ANTIVIRAL AND ANTITUMOR PLANT METABOLITES

Nouveaux composes antiviraux designes par le terme de calanolides, et leurs derives des formules (I) et (II), pouvant etre isoles a partir de vegetaux du genre Calophyllum. Les composes et leurs derives peuvent etre utilises seuls ou en combinaison avec d'autres agents antiviraux, en compositions, telles que des compositions pharmaceutiques, pour combattre la croissance ou la replication d'un virus, tel qu'un retrovirus en particulier le virus de l'immunodeficience humaine et, specifiquement le HIV-1 ou le HIV-2.

Composes antiviraux calanolides, compositions issues de ces composes et utilisations

L'invention porte sur des composes tricycliques qui inhibent selectivement l'activite de HIF-l?. L'invention porte egalement sur des methodes visant a reduire l'activite de HIF-1? et inhiber l'angiogenese, la tumorigenese et/ou la metastase chez un sujet. Selon certains modes de mise en oeuvre, les composes tricycliques inhibent curieusement l'activite de HIF-l? a des concentrations non cytotoxiques, ce qui evite les effets secondaires des medicaments associes a une cytotoxicite importante.

John H. Cardellina

Papers

The Lobatamides, Novel Cytotoxic Macrolides from Southwestern Pacific Tunicates.

Emmottene, from the Gorgonian Briareum polyanthes, Contains the First Naturally Occurring trans-Bicyclo(5.1.0)octane

Chapter Three ANTIVIRAL AND ANTITUMOR PLANT METABOLITES

Composes antiviraux calanolides, compositions issues de ces composes et utilisations

Composes tricycliques utiles comme inhibiteurs du mecanisme de signalisation hypoxique