J
John H. Cardellina
Researcher at Montana State University
Publications - 155
Citations - 7979
John H. Cardellina is an academic researcher from Montana State University. The author has contributed to research in topics: Calanolide A & Cell killing. The author has an hindex of 48, co-authored 154 publications receiving 7576 citations. Previous affiliations of John H. Cardellina include University of Illinois at Urbana–Champaign & United States Department of Commerce.
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Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.
William R. Gamble,Neil A. Durso,Richard W. Fuller,Chandra K. Westergaard,Tanya R. Johnson,Dan L. Sackett,Ernest Hamel,John H. Cardellina,Michael R. Boyd +8 more
TL;DR: In a comparative assay for inhibition of tubulin polymerization, the hemiasterlins were more potent than dolastatin 15 and equipotent with cryptophycin 1, but were somewhat less potent thandolastsatin 10.
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The Lobatamides, Novel Cytotoxic Macrolides from Southwestern Pacific Tunicates†
Tawnya C. McKee,Deborah L. Galinis,Lewis K. Pannell,John H. Cardellina,Jodi A. Laakso,Chris M. Ireland,Leanne Murray,Robert J. Capon,Michael R. Boyd +8 more
TL;DR: Analysis of the mean-graph differential cytotoxicity profiles of the lobatamides and the salicylihalamides showed high correlations with each other but not with members of the NCI's standard agents database, suggesting that these compounds appear to comprise a new mechanistic class, meriting further antitumor investigations.
Journal ArticleDOI
Challenges and opportunities confronting the botanical dietary supplement industry.
TL;DR: The intent of this review is to identify and characterize the scientific challenges confronting the botanical dietary supplements industry, explore opposing sides of some controversial issues, and outline an agenda for addressing the more acute problems.
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Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization
TL;DR: This is the first known example of a flavone with antimitotic activity and inhibited tubulin polymerization, inhibited the binding of [3H]-colchicine to tubulin, and induced mitotic figure formation in whole cells at cytotoxic concentrations.