https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

/pdf/aryl-aryl-bond-formation-one-century-after-the-discovery-of-1jdyxlkwix.pdf

Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.

Perp. punya vol. X. Flowering plant, eudicots : sapindales, cucurbitales, myrtaceae. Perp.punya: 1eks.

The Families And Genera Of Vascular Plants

In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chemical synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon-carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this Review, highlights of a number of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.

Palladium-catalyzed cross-coupling reactions in total synthesis.

The US National Cancer Institute (NCI) 60 human tumour cell line anticancer drug screen (NCI60) was developed in the late 1980s as an in vitro drug-discovery tool intended to supplant the use of transplantable animal tumours in anticancer drug screening. This screening model was rapidly recognized as a rich source of information about the mechanisms of growth inhibition and tumour-cell kill. Recently, its role has changed to that of a service screen supporting the cancer research community. Here I review the development, use and productivity of the screen, highlighting several outcomes that have contributed to advances in cancer chemotherapy.

The NCI60 human tumour cell line anticancer drug screen

Bioassay-guided fractionation of an extract from the marine alga Laurencia majuscula provided three brominated chamigrane sesquiterpenes (1–3). These compounds produced a novel pattern of antitumor activity against the National Cancer Institute's in vitro cell line panel. They were cytotoxic to certain cell lines in the colon cancer subpanel at concentrations 10–100 fold lower than the mean cytotoxic concentration observed in the other tumor subpanels.

Brominated Chamigrane Sesquiterpenes Produce a Novel Profile of Differential Cytotoxicity in the NCI in vitro Screen

Determining the absolute configuration of hindered secondary alcohols - a modified horeau's method

A crude organic solvent extract of ALANGIUM CF LONGIFLORUM exhibited potent inhibition of hypoxia-induced HIF-1 transcriptional activity in human U251 glioma cells Dereplication and bioactivity-guided fractionation, including Sephadex LH-20 and chiral HPLC chromatographies, led to the isolation of tubulosine ( 1), 9-desmethyltubulosine ( 2), and isotubulosine ( 3) Structures were verified by complete 1 H and 13 C assignments using 1D- and 2D-NMR techniques Tubulosine strongly inhibited HIF-1 transcriptional activity, isotubulosine was devoid of activity, and 9-desmethyltubulosine possessed 6-fold less potency than tubulosine

John H. Cardellina

Papers

Brominated Chamigrane Sesquiterpenes Produce a Novel Profile of Differential Cytotoxicity in the NCI in vitro Screen

Determining the absolute configuration of hindered secondary alcohols - a modified horeau's method

Separation and SAR Study of HIF-1α Inhibitory Tubulosines from Alangium cf. longiflorum

Semi-preparative separation of polyhydroxylated sterols using a β-cyclodextrin high-performance liquid chromatography column

Bissetone, a unique antimicrobial pyranone from the gorgonian