John H. Eckfeldt

TL;DR: Bookman et al. write to correct the impression given in the Commentary by Kohane and Taylor that the recommendations of the NHLBI Working Group “Reporting Genetic Results in Research Studies” included advice to return genetic information to research subjects only in cases where there is a proven or preventative intervention for the identified disorder.

TL;DR: My own experience in a recent ethylene glycol poisoning, where the diagnosis was not evident from the patient's history and made only post mortem, caused me to review the clinical indications and available methods for ethylene Glycol determination.

TL;DR: Examination of self-reported symptoms and clinical conditions in persons homozygous for HFE C282Y, the major HC-associated gene mutation, identified in the Hemochromatosis and Iron Overload Screening (HEIRS) Study, found significantly more chronic fatigue than controls.

TL;DR: The pathophysiology and clinical features of pheochromocytoma are reviewed, along with the biochemical approaches that have been used for confirming its diagnosis, and the authors' opinions on which test(s) to use and which patients screen are presented.