J
John J. Donnelly
Researcher at Chiron Corporation
Publications - 97
Citations - 9532
John J. Donnelly is an academic researcher from Chiron Corporation. The author has contributed to research in topics: DNA vaccination & Virus. The author has an hindex of 45, co-authored 97 publications receiving 9405 citations. Previous affiliations of John J. Donnelly include GlaxoSmithKline & United States Military Academy.
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Journal ArticleDOI
Heterologous protection against influenza by injection of DNA encoding a viral protein
Jeffrey B. Ulmer,John J. Donnelly,Suezanne E. Parker,Gary Rhodes,Philip L. Felgner,V. J. Dwarki,Stanislaw H. Gromkowski,R. Randall Deck,Corrille M. DeWitt,Arthur Friedman,Linda A. Hawe,Karen R. Leander,Douglas Martinez,Helen C. Perry,John W. Shiver,Donna L. Montgomery,Margaret A. Liu +16 more
TL;DR: To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
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DNA Vaccines: Progress and Challenges
TL;DR: The disappointing potency of the DNA vaccines in humans underscores the challenges encountered in the efforts to translate efficacy in preclinical models into clinical realities.
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Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus
John J. Donnelly,Arthur Friedman,Douglas Martinez,Donna L. Montgomery,John W. Shiver,Sherri L. Motzel,Jeffrey B. Ulmer,Margaret A. Liu +7 more
TL;DR: It is demonstrated that DNA vaccines may be more effective, particularly against different strains of virus, than inactivated virus or subvirion vaccines.
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Heterologous and Homologous Protection Against Influenza A by DNA Vaccination: Optimization of DNA Vectors
Donna L. Montgomery,John W. Shiver,Karen R. Leander,Helen C. Perry,Arthur Friedman,Douglas Martinez,Jeffrey B. Ulmer,John J. Donnelly,Margaret A. Liu +8 more
TL;DR: Immunization of mice with the NP and HA expression vectors resulted in protection from subsequent lethal challenges of influenza using either heterologous or homologous strains, respectively.
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Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice.
Marc Dupuis,Kimberly Denis-Mize,C.H. Woo,Cheryl Goldbeck,Mark Selby,Minchao Chen,Gillis R. Otten,Jeffrey B. Ulmer,John J. Donnelly,Gary Ott,Donald M. McDonald +10 more
TL;DR: It is indicated that distribution and cellular uptake significantly affect the immunogenicity of DNA vaccines.