J
John J. Skoko
Researcher at University of Pittsburgh
Publications - 30
Citations - 2081
John J. Skoko is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Phosphatase & RAD51. The author has an hindex of 19, co-authored 28 publications receiving 1839 citations. Previous affiliations of John J. Skoko include Johns Hopkins University.
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When NRF2 Talks, Who's Listening?
TL;DR: This review highlights recent observations on the molecular interactions and their functional consequences between NRF2 and the arylhydrocarbon receptor (AhR), NF-κB, p53, and Notch1 signaling pathways, which provide a multi-tiered, integrated response to chemical stresses.
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22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion
Radosveta Koldamova,Iliya Lefterov,Milos D. Ikonomovic,John J. Skoko,Preslav Lefterov,Barbara A. Isanski,Steven T. DeKosky,John S. Lazo +7 more
TL;DR: In this article, the ATP-binding cassette transporter A1 (ABCA1) was found to be a major regulator of peripheral cholesterol efflux and plasma high density lipoprotein metabolism.
22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid Secretion*
Radosveta Koldamova,Iliya Lefterov,Milos D. Ikonomovic,John J. Skoko,Preslav Lefterov,Barbara A. Isanski,Steven T. DeKosky,John S. Lazo +7 more
TL;DR: In non-neuronal and neuronal cells overexpressing a human Swedish variant of amyloid precursor protein, 22R-hydroxycholesterol and 9-cis-retinoic acid induced ABCA1 expression and increased apoA-I-mediated cholesterol efflux consequently decreasing cellular cholesterol content.
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The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1
Andreas Vogt,Aletheia Tamewitz,John J. Skoko,Rachel P. Sikorski,Kenneth A. Giuliano,John S. Lazo +5 more
TL;DR: Sanguinarine, a plant alkaloid with known antibiotic and antitumor activity but no primary cellular target, is identified as a potent and selective inhibitor of MKP-1, and the utility of a chemical complementation assay linked with multiparameter high content cellular screening is illustrated.
Journal ArticleDOI
Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling
Nobunao Wakabayashi,John J. Skoko,John J. Skoko,Dionysios V. Chartoumpekis,Shoko Kimura,Stephen L. Slocum,Stephen L. Slocum,Kentaro Noda,Dushani L. Palliyaguru,Masahiro Fujimuro,Patricia A. Boley,Yugo Tanaka,Norihisa Shigemura,Shyam Biswal,Masayuki Yamamoto,Thomas W. Kensler +15 more
TL;DR: It appears that Notch-to-Nrf2 signaling is another important determinant in liver development and function and promotes cell-cell cytoprotective signaling responses.