J
John J. Thaden
Researcher at Texas A&M University
Publications - 39
Citations - 4486
John J. Thaden is an academic researcher from Texas A&M University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 26 publications receiving 3646 citations. Previous affiliations of John J. Thaden include University of Arkansas for Medical Sciences & Johns Hopkins University.
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Journal ArticleDOI
Proposed minimum reporting standards for chemical analysis
Lloyd W. Sumner,Alexander Amberg,Dave Barrett,Michael H. Beale,Richard D. Beger,Clare A. Daykin,Teresa W.-M. Fan,Oliver Fiehn,Royston Goodacre,Julian L. Griffin,Thomas Hankemeier,Nigel Hardy,James M. Harnly,Richard M. Higashi,Joachim Kopka,Andrew N. Lane,John C. Lindon,Philip J. Marriott,Andrew W. Nicholls,Michael D. Reily,John J. Thaden,Mark R. Viant +21 more
TL;DR: This article proposes the minimum reporting standards related to the chemical analysis aspects of metabolomics experiments including: sample preparation, experimental analysis, quality control, metabolite identification, and data pre-processing.
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Remarkable longevity and stress resistance of nematode PI3K-null mutants.
TL;DR: PI3K‐null adults, although a little less thermotolerant, are considerably more resistant to oxidative and electrophilic stresses than worms bearing normal or less long‐lived alleles, and are attributed to elimination of residual and maternally contributed PI3KCS or its products, and consequent modification of kinase signaling cascades.
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Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction
TL;DR: Conditions which allow robust discrimination for PCR-mediated analysis of single-nucleotide polymorphisms (SNPs), and for reduction in complexity of anchor-ligation PCR products are defined.
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Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants
Robert J. Shmookler Reis,Robert J. Shmookler Reis,Lulu Xu,Hoonyong Lee,Minho Chae,John J. Thaden,Puneet Bharill,Cagdas Tazearslan,Eric R. Siegel,Ramani Alla,Piotr Zimniak,Piotr Zimniak,Srinivas Ayyadevara,Srinivas Ayyadevara +13 more
TL;DR: A functional model in which longevity benefits from a reduction in lipid peroxidation substrates, offset by a coordinate decline in fatty-acid chain length to maintain membrane fluidity is suggested, tested by disrupting the underlying steps in lipid biosynthesis.
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Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin
Bill J. Gurley,Martha A. Hubbard,D. Keith Williams,John J. Thaden,Yudong Tong,W. Brooks Gentry,Philip J. Breen,Danielle Julie Carrier,Shreekar Cheboyina +8 more
TL;DR: Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo, and midazolam pharmacokinetics was unaffected by milk thistle or black cohOSH.