Journal ArticleDOI
The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.
TLDR
The residual behavioural effects of 8-OH-DPAT in reserpinised rats may, therefore, reflect the consequences of stimulation of the putative 5-HT1A receptor.About:
This article is published in European Journal of Pharmacology.The article was published on 1984-11-13. It has received 689 citations till now. The article focuses on the topics: NAN-190 & Receptor antagonist.read more
Citations
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Journal ArticleDOI
A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
Journal ArticleDOI
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
TL;DR: Evidence for the occurrence of MDMA-induced neurotoxic damage in human users remains equivocal, although some biochemical and functional data suggest that damage may occur in the brains of heavy users.
Journal Article
Autoregulation of Serotonin Neurons: Role in Antidepressant Drug Action
Graciela Piñeyro,Pierre Blier +1 more
TL;DR: The existence of an endogenous vasoconstrictor in blood serum and the presence in the gut of a substance that increases intestinal motility had been known to scientists since the beginning of the century.
Journal ArticleDOI
Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats.
TL;DR: The selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5,7- dihydroxytryptamine was associated only with a significant loss of 5- HT1A binding to the dorsal raphe nucleus and of 3H-8-hydroxy-2- (N-dipropylamino)tetralin as the ligand.
Journal ArticleDOI
[3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain.
TL;DR: The postsynaptic hippocampal [3H]8‐OH‐DPAT binding sites are probably identical to the 5‐HT1A, subsites, but the relationship between the presynaptic binding sites and the Presynaptic autoreceptors controlling 5‐ HT release deserves further investigation.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal Article
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
TL;DR: It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
Journal ArticleDOI
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
Journal ArticleDOI
Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors
Josée E. Leysen,Frans Awouters,Ludo Edmond Josephine Kennis,Pierre M. Laduron,Jan Vandenberk,P. A. J. Janssen +5 more
TL;DR: It is concluded that R 41 468 will be a particularly suitable tool to antagonize 5-HT action mediated by5-HT2 receptors.
Journal ArticleDOI
Discrimination of Multiple [3H]5-Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain
TL;DR: Saturation studies of [3H]5‐HT binding assayed in the absence or presence of 1 μM‐spiperone reveal a parallel shift in the Scatchard plot with no change in the dissociation constant of [2‐12 nM], but a significant decrease in the number of specific binding sites.