J
John R. Grainger
Researcher at University of Manchester
Publications - 63
Citations - 7350
John R. Grainger is an academic researcher from University of Manchester. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 29, co-authored 50 publications receiving 6197 citations. Previous affiliations of John R. Grainger include Manchester Academic Health Science Centre & National Institutes of Health.
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Journal ArticleDOI
Generation of pathogenic T H 17 cells in the absence of TGF-β signalling
Kamran Ghoreschi,Arian Laurence,Xiang-Ping Yang,Cristina M. Tato,Mandy J. McGeachy,Joanne E. Konkel,Haydeé L. Ramos,Lai Wei,Todd S. Davidson,Nicolas Bouladoux,John R. Grainger,Qian Chen,Yuka Kanno,Wendy T. Watford,Hong-Wei Sun,Gérard Eberl,Ethan M. Shevach,Yasmine Belkaid,Daniel J. Cua,Wanjun Chen,John J. O'Shea +20 more
TL;DR: In this article, the authors show that T(H)17 differentiation can occur in the absence of TGF-β signalling, without the need of transforming growth factor (TGF)-β1.
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Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity
TL;DR: Current understanding of the growing number of individual helminth mediators that have been shown to target key receptors or pathways in the mammalian immune system is summarised.
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Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes
Claudia Jakubzick,Claudia Jakubzick,Emmanuel L. Gautier,Sophie L. Gibbings,Dorothy K. Sojka,Andreas Schlitzer,Theodore E. Johnson,Stoyan Ivanov,Qiaonan Duan,Shashi Bala,Tracy Condon,Nico van Rooijen,John R. Grainger,Yasmine Belkaid,Avi Ma'ayan,David W. H. Riches,Wayne M. Yokoyama,Florent Ginhoux,Peter M. Henson,Gwendalyn J. Randolph,Gwendalyn J. Randolph +20 more
TL;DR: It is shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs) and can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophage by default.
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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.
Xiang-Ping Yang,Kamran Ghoreschi,Scott M. Steward-Tharp,Jaime Rodriguez-Canales,Jinfang Zhu,John R. Grainger,Kiyoshi Hirahara,Hong-Wei Sun,Lai Wei,Golnaz Vahedi,Yuka Kanno,John J. O'Shea,Arian Laurence +12 more
TL;DR: Deletion of the gene encoding the transcription factor STAT3 in T cells abrogated IL-17 production and attenuated autoimmunity associated with IL-2 deficiency and 'Titration' of the relative activation of STAT3 and STAT5 modulated the specification of cells to the IL- 17-producing helper T cell (TH17 cell) subset.
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The Role of Retinoic Acid in Tolerance and Immunity
Jason A. Hall,Jason A. Hall,John R. Grainger,Sean P. Spencer,Sean P. Spencer,Yasmine Belkaid +5 more
TL;DR: A comprehensive overview of the cell types and factors that control the production of RA are provided and how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology is discussed.