J
John Spencer
Researcher at University of Sussex
Publications - 206
Citations - 6040
John Spencer is an academic researcher from University of Sussex. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 36, co-authored 196 publications receiving 5266 citations. Previous affiliations of John Spencer include Universidade Federal do Rio Grande do Sul & University of Greenwich.
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Journal ArticleDOI
The potential of palladacycles: more than just precatalysts
Journal ArticleDOI
Palladacycles − An Old Organometallic Family Revisited: New, Simple, and Efficient Catalyst Precursors for Homogeneous Catalysis
TL;DR: Palladacycles as discussed by the authors are a new family of organometallic precursors, typically containing four or six-electron donor anionic metallated ligands, and have been successfully exploited in catalytic reactions ranging from classical hydrogenations to enantioselective aldol-type condensations.
Journal ArticleDOI
On the Noninnocent Nature of 1,3-Dialkylimidazolium Ionic Liquids†
Jairton Dupont,John Spencer +1 more
Journal ArticleDOI
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.
Karin Tuschl,Esther Meyer,Leonardo E Valdivia,Ningning Zhao,Chris Dadswell,Alaa Abdul-Sada,Christina Hung,Michael A. Simpson,Wui K. Chong,Thomas S. Jacques,Randy L Woltjer,Simon Eaton,Allison Gregory,Lynn Sanford,Eleanna Kara,Eleanna Kara,Henry Houlden,Stephan M. Cuno,Holger Prokisch,Lorella Valletta,Valeria Tiranti,Rasha Younis,Eamonn R. Maher,John Spencer,Ania Straatman-Iwanowska,Paul Gissen,Laila Am Selim,Guillem Pintos-Morell,Wifredo Coroleu-Lletget,Shekeeb S. Mohammad,Sangeetha Yoganathan,Russell C. Dale,Maya Thomas,Jason Rihel,Olaf Bodamer,Caroline A. Enns,Susan J. Hayflick,Peter E. Clayton,Philippa B. Mills,Manju A Kurian,Stephen W. Wilson +40 more
TL;DR: It is demonstrated that SLC39A14 functions as a pivotal manganese transporter in vertebrates and can lead to striking clinical improvement in patients with a novel autosomal recessive mangansese transporter defect caused by mutations in SLC 39A14.
Journal ArticleDOI
Small molecule induced reactivation of mutant p53 in cancer cells
Xiangrui Liu,Rainer Wilcken,Andreas C. Joerger,Irina Chuckowree,Jahangir Amin,John Spencer,Alan R. Fersht +6 more
TL;DR: The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.