J
J. Brent Richards
Researcher at McGill University
Publications - 238
Citations - 24369
J. Brent Richards is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Mendelian randomization. The author has an hindex of 61, co-authored 193 publications receiving 19382 citations. Previous affiliations of J. Brent Richards include King's College London & Jewish General Hospital.
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Journal ArticleDOI
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,C Sidore,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Chen,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +117 more
TL;DR: A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
Journal ArticleDOI
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Thomas J. Wang,Feng Zhang,J. Brent Richards,Bryan Kestenbaum,Joyce B. J. van Meurs,Diane J. Berry,Douglas P. Kiel,Elizabeth A. Streeten,Claes Ohlsson,Daniel L. Koller,Leena Peltonen,Leena Peltonen,Jason D. Cooper,Paul F. O'Reilly,Denise K. Houston,Nicole L. Glazer,Liesbeth Vandenput,Munro Peacock,Julia Shi,Fernando Rivadeneira,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Pouta Anneli,Ian H. de Boer,Massimo Mangino,Bernet S. Kato,Deborah J. Smyth,Sarah L. Booth,Paul F. Jacques,Greg L. Burke,Mark O. Goodarzi,Ching-Lung Cheung,Myles Wolf,Kenneth Rice,David Goltzman,Nick Hidiroglou,Martin Ladouceur,Nicholas J. Wareham,Lynne J. Hocking,Deborah J. Hart,Nigel K Arden,Cyrus Cooper,Suneil Malik,William D. Fraser,Anna Liisa Hartikainen,Guangju Zhai,Helen M. Macdonald,Nita G. Forouhi,Ruth J. F. Loos,David M. Reid,Alan Hakim,Elaine M. Dennison,Yongmei Liu,Chris Power,Helen Stevens,Laitinen Jaana,Ramachandran S. Vasan,Nicole Soranzo,Nicole Soranzo,Jörg Bojunga,Bruce M. Psaty,Mattias Lorentzon,Tatiana Foroud,Tamara B. Harris,Albert Hofman,John-Olov Jansson,Jane A. Cauley,André G. Uitterlinden,Quince Gibson,Marjo-Riitta Järvelin,David Karasik,David S. Siscovick,Michael J. Econs,Stephen B. Kritchevsky,Jose C. Florez,John A. Todd,Josée Dupuis,Elina Hyppönen,Tim D. Spector +79 more
TL;DR: In this article, a genome-wide association study of 25-hydroxyvitamin D concentrations in 33,996 individuals of European descent from 15 cohorts was conducted to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,Carlo Sidorel,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Che,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +110 more
TL;DR: In this article, a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry is presented.
Journal ArticleDOI
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada,Unnur Styrkarsdottir,Evangelos Evangelou,Yi-Hsiang Hsu,Emma L. Duncan,Evangelia E. Ntzani,Ling Oei,Omar M. E. Albagha,Najaf Amin,John P. Kemp,Daniel L. Koller,Guo Shuai Li,Ching-Ti Liu,Ryan L. Minster,Alireza Moayyeri,Liesbeth Vandenput,Dana Willner,Su-Mei Xiao,Laura M. Yerges-Armstrong,Hou-Feng Zheng,Nerea Alonso,Joel Eriksson,Candace M. Kammerer,Stephen Kaptoge,Paul Leo,Gudmar Thorleifsson,Scott Wilson,Scott Wilson,James F. Wilson,Ville Aalto,Ville Aalto,Markku Alen,Aaron K. Aragaki,Thor Aspelund,Zoe H. Dailiana,David Duggan,Melissa Nolan Garcia,Natalia Garcia-Giralt,Sylvie Giroux,Göran Hallmans,Lynne J. Hocking,L. B. Husted,Karen A. Jameson,Khusainova Ri,Ghi Su Kim,Charles Kooperberg,Theodora Koromila,Marcin Kruk,Marika Laaksonen,Andrea Z. LaCroix,Seung-Hun Lee,P. C. Leung,Joshua R. Lewis,Laura Masi,Simona Mencej-Bedrač,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Millan S. Patel,Janez Prezelj,Lynda M. Rose,Serena Scollen,Kristin Siggeirsdottir,Albert V. Smith,Olle Svensson,Stella Trompet,Olivia Trummer,Natasja M. van Schoor,Jean Woo,Kun Zhu,Susana Balcells,Maria Luisa Brandi,Brendan M. Buckley,Sulin Cheng,Claus Christiansen,Cyrus Cooper,George Dedoussis,Ian Ford,Morten Frost,Morten Frost,David Goltzman,Jesús González-Macías,Mika Kähönen,Magnus Karlsson,Elza Khusnutdinova,Jung-Min Koh,Panagoula Kollia,Bente L. Langdahl,William D. Leslie,Paul Lips,Östen Ljunggren,Roman S. Lorenc,Janja Marc,Dan Mellström,Barbara Obermayer-Pietsch,José M. Olmos,Ulrika Pettersson-Kymmer,David M. Reid,José A. Riancho,Paul M. Ridker,François Rousseau,P. Eline Slagboom,Nelson Ls Tang,Roser Urreizti,Wim Van Hul,Jorma Viikari,María T. Zarrabeitia,Yurii S. Aulchenko,Martha C. Castaño-Betancourt,Elin Grundberg,Elin Grundberg,Lizbeth Herrera,Thorvaldur Ingvarsson,Hrefna Johannsdottir,Tony Kwan,Rui Jian Li,Robert Luben,Carolina Medina-Gomez,Stefan T Palsson,Sjur Reppe,Jerome I. Rotter,Gunnar Sigurdsson,Joyce B. J. van Meurs,Dominique J. Verlaan,Frances M K Williams,Andrew R. Wood,Yanhua Zhou,Kaare M. Gautvik,Tomi Pastinen,Soumya Raychaudhuri,Soumya Raychaudhuri,Jane A. Cauley,Daniel I. Chasman,Graeme R. Clark,Steven R. Cummings,Patrick Danoy,Elaine M. Dennison,Richard Eastell,John A. Eisman,John A. Eisman,Vilmundur Gudnason,Albert Hofman,Rebecca D. Jackson,Graeme Jones,J. Wouter Jukema,Kay-Tee Khaw,Terho Lehtimäki,Yongmei Liu,Mattias Lorentzon,Eugene V. McCloskey,Braxton D. Mitchell,Kannabiran Nandakumar,Geoffrey C. Nicholson,Ben A. Oostra,Munro Peacock,Huibert A. P. Pols,Richard L. Prince,Olli T. Raitakari,Olli T. Raitakari,Ian R. Reid,John A Robbins,Philip N. Sambrook,Pak C. Sham,Alan R. Shuldiner,Frances A. Tylavsky,Cornelia M. van Duijn,Nicholas J. Wareham,L. Adrienne Cupples,Michael J. Econs,David M. Evans,Tamara B. Harris,Annie W.C. Kung,Bruce M. Psaty,Jonathan Reeve,Tim D. Spector,Elizabeth A. Streeten,M. Carola Zillikens,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Claes Ohlsson,David Karasik,J. Brent Richards,Matthew A. Brown,Kari Stefansson,Kari Stefansson,André G. Uitterlinden,Stuart H. Ralston,John P. A. Ioannidis,John P. A. Ioannidis,Douglas P. Kiel,Fernando Rivadeneira +190 more
TL;DR: Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
Journal ArticleDOI
An atlas of genetic influences on human blood metabolites
So-Youn Shin,Eric B. Fauman,Ann-Kristin Petersen,Jan Krumsiek,Rita Santos,Jie Huang,Matthias Arnold,Idil Erte,Vincenzo Forgetta,Tsun-Po Yang,Klaudia Walter,Cristina Menni,Lu Chen,Lu Chen,Louella Vasquez,Ana M. Valdes,Ana M. Valdes,Craig L. Hyde,Vicky Wang,Daniel Ziemek,Phoebe M. Roberts,Li Xi,Elin Grundberg,Melanie Waldenberger,J. Brent Richards,Robert P. Mohney,Michael V. Milburn,Sally John,Jeff K. Trimmer,Fabian J. Theis,John P. Overington,Karsten Suhre,M. Julia Brosnan,Christian Gieger,Gabi Kastenmüller,Tim D. Spector,Nicole Soranzo +36 more
TL;DR: The most comprehensive exploration of genetic loci influencing human metabolism thus far, comprising 7,824 adult individuals from 2 European population studies, is reported, reporting genome-wide significant associations at 145 metabolic loci and their biochemical connectivity with more than 400 metabolites in human blood.