M
Matthew Tesarfreund
Researcher at University of California, Los Angeles
Publications - 2
Citations - 184
Matthew Tesarfreund is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Genetic enhancement & Pseudomonas exotoxin. The author has an hindex of 2, co-authored 2 publications receiving 172 citations.
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Journal ArticleDOI
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Marianela Candolfi,Kader Yagiz,David Foulad,Gabrielle E. Alzadeh,Matthew Tesarfreund,A.K.M. Ghulam Muhammad,Mariana Puntel,Kurt M. Kroeger,Chunyan Liu,Sharon Lee,James F. Curtin,Gwendalyn D. King,Jonathan Lerner,Katsuaki Sato,Yohei Mineharu,Weidong Xiong,Pedro R. Lowenstein,Maria G. Castro +17 more
TL;DR: The results indicate that Ad-TK+GCV+Ad-Flt3L exhibit the highest efficacy and safety profile among the several proapoptotic approaches tested.
Journal ArticleDOI
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics
Marianela Candolfi,Weidong Xiong,Kader Yagiz,Chunyan Liu,Akm Ghulam Muhammad,Mariana Puntel,David Foulad,Ali Zadmehr,Gabrielle E. Ahlzadeh,Kurt M. Kroeger,Matthew Tesarfreund,Sharon Lee,Waldemar Debinski,Dhruv Sareen,Clive N. Svendsen,Ronald Rodriguez,Pedro R. Lowenstein,Maria G. Castro +17 more
TL;DR: A regulatable adenoviral vector encoding a mutated human IL-13 fused to Pseudomonas exotoxin that specifically binds to IL13Rα2 to provide sustained expression, effective anti-GBM cytotoxicity, and minimal neurotoxicity is developed, representing a significant advance in the development of targeted therapeutics for GBM.