Jonathan P. Katz

TL;DR: The first in vivo evidence that Klf4 is a goblet cell-specific differentiation factor in the colon is provided, providing a crucial role in colonic epithelial cell differentiation in vivo.

TL;DR: It is demonstrated that Kruppel-like factor 4 expression markedly decreases inflammatory cell adhesion to the endothelial surface and prolongs clotting time under inflammatory states, which implicate Kruppellike factor 4 as a novel regulator of endothelial activation in response to pro-inflammatory stimuli.

TL;DR: The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.

TL;DR: It is shown that KLF4/GKLF is expressed in a monocyte‐restricted and stage‐specific pattern during myelopoiesis and functions to promote monocyte differentiation.

TL;DR: A central role is invoked in the regulatory control of islet genes essential for glucose homeostasis in vivo in mice homozygous for a null mutation in the winged helix transcription factor HNF3alpha.