Frank Rosenbauer

TL;DR: It is found that mouse microglia were derived from primitive c-kit+ erythromyeloid precursors that were detected in the yolk sac as early as 8 d post conception and microgliogenesis was not only dependent on the transcription factor Pu.1, but also required Irf8, which was vital for the development of the A2 population, whereas Myb, Id2, Batf3 and Klf4 were not required.

TL;DR: A novel role for ICSBP is suggested in regulating the proliferation and differentiation of hematopoietic progenitor cells in mice with a null mutation of ICS BP.

TL;DR: Transcription factors have been shown to be key determinants in the orchestration of myeloid identity and differentiation fates, and therapies designed to restore defective transcription factor functions are an attractive option in the treatment ofMyeloid and other human cancers.

TL;DR: Results suggest that tightly graded reduction, rather than complete loss, of a lineage-indispensable transcription factor can induce AML.

TL;DR: This work shows that alternative functional programs of hematopoietic stem cells (HSCs) are governed by gradual differences in methylation levels and identifies DNA methylation as an essential epigenetic mechanism to protect stem cells from premature activation of predominant differentiation programs.