J
Jorge Ruiz-Orera
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 36
Citations - 1255
Jorge Ruiz-Orera is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Ribosome profiling. The author has an hindex of 9, co-authored 24 publications receiving 794 citations. Previous affiliations of Jorge Ruiz-Orera include Pompeu Fabra University.
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Journal ArticleDOI
Long non-coding RNAs as a source of new peptides
TL;DR: It is found that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes, indicating that they play an important role in de novo protein evolution.
Journal ArticleDOI
Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx.
Federico Abascal,André Corvelo,Fernando Cruz,Fernando Cruz,José Luis Villanueva-Cañas,Anna Vlasova,Marina Marcet-Houben,Begoña Martínez-Cruz,Jade Yu Cheng,Pablo Prieto,Víctor Quesada,Javier Quilez,Gang Li,Francisca Garcia,Miriam Rubio-Camarillo,Leonor Frias,Paolo Ribeca,Salvador Capella-Gutierrez,Jose Manuel Rodriguez,Francisco Câmara,Ernesto Lowy,Luca Cozzuto,Ionas Erb,Michael L. Tress,Jose Luis Rodriguez-Ales,Jorge Ruiz-Orera,Ferran Reverter,Mireia Casas-Marce,Laura Soriano,Javier R. Arango,Sophia Derdak,Beatriz Galán,Julie Blanc,Marta Gut,Belen Lorente-Galdos,Marta Andrés-Nieto,Carlos López-Otín,Alfonso Valencia,Ivo Gut,José Luis García,Roderic Guigó,William J. Murphy,Aurora Ruiz-Herrera,Tomas Marques-Bonet,Tomas Marques-Bonet,Guglielmo Roma,Cedric Notredame,Thomas Mailund,M. Mar Albà,M. Mar Albà,Toni Gabaldón,Toni Gabaldón,Tyler Alioto,José A. Godoy +53 more
TL;DR: A series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution are identified.
Journal ArticleDOI
Origins of De Novo Genes in Human and Chimpanzee
Jorge Ruiz-Orera,Jessica Hernandez-Rodriguez,Cristina Chiva,Eduard Sabidó,Ivanela Kondova,Ronald E. Bontrop,Tomas Marques-Bonet,Tomas Marques-Bonet,M. Mar Albà,M. Mar Albà +9 more
TL;DR: Data from in-depth sequencing of the transcriptomes of four mammalian species support a model in which frequently-occurring new transcriptional events in the genome provide the raw material for the evolution of new proteins.
Journal ArticleDOI
Translation of neutrally evolving peptides provides a basis for de novo gene evolution
Jorge Ruiz-Orera,Pol Verdaguer-Grau,José Luis Villanueva-Cañas,Xavier Messeguer,M. Mar Albà,M. Mar Albà +5 more
TL;DR: It is concluded that the pervasive translation of the transcriptome provides plenty of material for the evolution of new functional proteins and the translation of these neutrally evolving peptides may be facilitated by the chance occurrence of open reading frames with a favourable codon composition.
Journal ArticleDOI
Translation of Small Open Reading Frames: Roles in Regulation and Evolutionary Innovation.
TL;DR: This work proposes a comprehensive classification that includes the new types of translated ORFs in addition to standard proteins, and it also includes small regulatory open reading frames (ORFs), functional micropeptides, de novo proteins and the pervasive translation of likely nonfunctional proteins.