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Sophia Derdak
Researcher at Medical University of Vienna
Publications - 48
Citations - 1503
Sophia Derdak is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Imatinib mesylate & ABL. The author has an hindex of 13, co-authored 41 publications receiving 1236 citations. Previous affiliations of Sophia Derdak include Pompeu Fabra University.
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Journal ArticleDOI
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
Tyler Alioto,Ivo Buchhalter,Sophia Derdak,Barbara Hutter,Matthew D. Eldridge,Eivind Hovig,Lawrence E. Heisler,Timothy Beck,Jared T. Simpson,Laurie Tonon,Anne Sophie Sertier,Ann-Marie Patch,Ann-Marie Patch,Natalie Jäger,Natalie Jäger,Philip Ginsbach,Ruben M. Drews,Nagarajan Paramasivam,Rolf Kabbe,Sasithorn Chotewutmontri,Nicolle Diessl,Christopher Previti,Sabine Schmidt,Benedikt Brors,Lars Feuerbach,Michael Heinold,Susanne Gröbner,Andrey Korshunov,Patrick S. Tarpey,Adam Butler,Jonathan Hinton,David T. Jones,Andrew Menzies,Keiran Raine,Rebecca Shepherd,Lucy Stebbings,Jon W. Teague,Paolo Ribeca,Francesc Castro Giner,Sergi Beltran,Emanuele Raineri,Marc Dabad,Simon Heath,Marta Gut,Robert E. Denroche,Nicholas J. Harding,Takafumi N. Yamaguchi,Akihiro Fujimoto,Hidewaki Nakagawa,Víctor Quesada,Rafael Valdés-Mas,Sigve Nakken,Daniel Vodak,Lawrence Bower,Andy G. Lynch,Charlotte Anderson,Charlotte Anderson,Nicola Waddell,Nicola Waddell,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Myron Peto,Paul T. Spellman,Minghui He,Cyriac Kandoth,Semin Lee,John Zhang,John Zhang,Louis Letourneau,Singer Ma,Sahil Seth,David Torrents,Liu Xi,David A. Wheeler,Carlos López-Otín,Elias Campo,Peter J. Campbell,Paul C. Boutros,Xose S. Puente,Daniela S. Gerhard,Stefan M. Pfister,Stefan M. Pfister,John Douglas Mcpherson,John Douglas Mcpherson,Thomas J. Hudson,Thomas J. Hudson,Matthias Schlesner,Peter Lichter,Roland Eils,Roland Eils,David T. W. Jones,Ivo Gut +93 more
TL;DR: It is shown that using PCR-free methods and increasing sequencing depth to ∼100 × shows benefits, as long as the tumour:control coverage ratio remains balanced, and many issues are in fact easy to remedy and have an immediate positive impact on mutation detection accuracy.
Journal ArticleDOI
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
Karl J. Aichberger,Matthias Mayerhofer,Maria-Theresa Krauth,Hans Skvara,Stefan Florian,Karoline Sonneck,Cahit Akgul,Sophia Derdak,Winfried F. Pickl,Volker Wacheck,Edgar Selzer,Brett P. Monia,Richard Moriggl,Peter Valent,Christian Sillaber +14 more
TL;DR: MCL-1 is identified as a BCR/ABL-dependent survival factor and interesting target in CML, and the mcl-1 ASO was found to synergize with imatinib in producing growth inhibition in these cells.
Journal ArticleDOI
Development and validation of a 20K Single Nucleotide Polymorphism (SNP) whole genome genotyping array for apple (Malus × domestica Borkh)
Luca Bianco,Alessandro Cestaro,Daniel J. Sargent,Elisa Banchi,Sophia Derdak,Mario Di Guardo,Silvio Salvi,Johannes Jansen,Roberto Viola,Ivo Gut,François Laurens,David Chagné,Riccardo Velasco,Eric van de Weg,Michela Troggio +14 more
TL;DR: The newly developed array with its high density of polymorphic validated SNPs is expected to be of great utility for Pedigree-Based Analysis and Genomic Selection, and will also be a valuable tool to help dissect the genetic mechanisms controlling important fruit quality traits.
Journal ArticleDOI
Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx.
Federico Abascal,André Corvelo,Fernando Cruz,Fernando Cruz,José Luis Villanueva-Cañas,Anna Vlasova,Marina Marcet-Houben,Begoña Martínez-Cruz,Jade Yu Cheng,Pablo Prieto,Víctor Quesada,Javier Quilez,Gang Li,Francisca Garcia,Miriam Rubio-Camarillo,Leonor Frias,Paolo Ribeca,Salvador Capella-Gutierrez,Jose Manuel Rodriguez,Francisco Câmara,Ernesto Lowy,Luca Cozzuto,Ionas Erb,Michael L. Tress,Jose Luis Rodriguez-Ales,Jorge Ruiz-Orera,Ferran Reverter,Mireia Casas-Marce,Laura Soriano,Javier R. Arango,Sophia Derdak,Beatriz Galán,Julie Blanc,Marta Gut,Belen Lorente-Galdos,Marta Andrés-Nieto,Carlos López-Otín,Alfonso Valencia,Ivo Gut,José Luis García,Roderic Guigó,William J. Murphy,Aurora Ruiz-Herrera,Tomas Marques-Bonet,Tomas Marques-Bonet,Guglielmo Roma,Cedric Notredame,Thomas Mailund,M. Mar Albà,M. Mar Albà,Toni Gabaldón,Toni Gabaldón,Tyler Alioto,José A. Godoy +53 more
TL;DR: A series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution are identified.
Journal ArticleDOI
Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds
Karl J. Aichberger,Matthias Mayerhofer,Maria Theresa Krauth,Anja Vales,Rudin Kondo,Sophia Derdak,Winfried F. Pickl,Edgar Selzer,Michael W. Deininger,Brian J. Druker,Christian Sillaber,Harald Esterbauer,Peter Valent +12 more
TL;DR: The data identify BCR/ABL as a Bim suppressor in CML cells and suggest that reexpression of Bim by novel tyrosine kinase inhibitors, proteasome inhibition, or by targeting signaling pathways downstream of BCR-ABL may be an attractive therapeutic approach in imatinib-resistant CML.