J
Joriene C. de Nooij
Researcher at Columbia University
Publications - 2
Citations - 145
Joriene C. de Nooij is an academic researcher from Columbia University. The author has contributed to research in topics: Gene & Enhancer. The author has an hindex of 1, co-authored 2 publications receiving 111 citations.
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Journal ArticleDOI
Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Rita Bardoni,Vivianne L. Tawfik,Dong Wang,Amaury François,Carlos Solorzano,Scott A. Shuster,Papiya Choudhury,Chiara Betelli,Colleen Cassidy,Kristen Smith,Joriene C. de Nooij,Françoise Mennicken,Dajan O'Donnell,Brigitte L. Kieffer,C. Jeffrey Woodbury,Allan I. Basbaum,Amy B. MacDermott,Grégory Scherrer +17 more
TL;DR: It is demonstrated that DOR activation at the central terminals of myelinated mechanoreceptors depresses synaptic input to the spinal dorsal horn, via the inhibition of voltage-gated calcium channels, which reveals a molecular mechanism by which opioids modulate cutaneous mechanosensation.
Journal ArticleDOI
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity.
Ashwin Nair,Michael Closser,Yuchun Guo,Ping Wang,Tulsi Patel,Sumin Jang,Jennifer Hammelman,Joriene C. de Nooij,Rachel Kopunova,Esteban O. Mazzoni,Yijun Ruan,David K. Gifford,Hynek Wichterle +12 more
TL;DR: In this paper, the authors show that motor neuron enhancers are broadly distributed across the large chromatin domains, suggesting that acquisition of new enhancers might be a fundamental process underlying the evolutionary increase in cellular complexity.