D
Dong Wang
Researcher at Stanford University
Publications - 13
Citations - 540
Dong Wang is an academic researcher from Stanford University. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Synapse. The author has an hindex of 9, co-authored 13 publications receiving 397 citations. Previous affiliations of Dong Wang include Hong Kong University of Science and Technology.
Papers
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Journal ArticleDOI
Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Rita Bardoni,Vivianne L. Tawfik,Dong Wang,Amaury François,Carlos Solorzano,Scott A. Shuster,Papiya Choudhury,Chiara Betelli,Colleen Cassidy,Kristen Smith,Joriene C. de Nooij,Françoise Mennicken,Dajan O'Donnell,Brigitte L. Kieffer,C. Jeffrey Woodbury,Allan I. Basbaum,Amy B. MacDermott,Grégory Scherrer +17 more
TL;DR: It is demonstrated that DOR activation at the central terminals of myelinated mechanoreceptors depresses synaptic input to the spinal dorsal horn, via the inhibition of voltage-gated calcium channels, which reveals a molecular mechanism by which opioids modulate cutaneous mechanosensation.
Journal ArticleDOI
Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Dong Wang,Vivianne L. Tawfik,Gregory Corder,Sarah A. Low,Amaury François,Allan I. Basbaum,Grégory Scherrer +6 more
TL;DR: It is demonstrated that in the discrete DOR-MOR co-expressing nociceptive neurons, the two receptors internalize and function independently, and conditional knockout experiments revealed that DORs selectively regulate mechanical pain by controlling the excitability of somatostatin-positive dorsal horn interneurons.
Journal ArticleDOI
Mechanosensitive gating of CFTR
Wei Kevin Zhang,Dong Wang,Dong Wang,Yuanyuan Duan,Michael M.T. Loy,Hsiao Chang Chan,Pingbo Huang +6 more
TL;DR: This study shows that CFTR is robustly activated by membrane stretch induced by negative pressures as small as 5 mmHg at the single-channel, cellular and tissue levels, and demonstrates for the first time a mechanosensitive anion channel with a clearly defined molecular identity.
Journal ArticleDOI
GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis
TL;DR: In vivo whole-cell patch-clamp recording from AFD is used to show that loss of GCY-8, but not of GC-18 or GC-23, reduces or eliminates ThRCs, identifying this rGC as a crucial signaling element and proposing a signaling network to account for ThRC activation and adaptation.
Journal ArticleDOI
Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
TL;DR: The results suggest that opioid effects on pain and reward may be shaped by the relative selectivity of opioid drugs to the specific circuit components.