J
Jos Boekhorst
Researcher at Radboud University Nijmegen
Publications - 96
Citations - 7244
Jos Boekhorst is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Microbiome & Gene. The author has an hindex of 40, co-authored 86 publications receiving 6192 citations. Previous affiliations of Jos Boekhorst include Utrecht University & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Complete genome sequence of Lactobacillus plantarum WCFS1
Michiel Kleerebezem,Jos Boekhorst,Richard van Kranenburg,Douwe Molenaar,Oscar P. Kuipers,R.J. Leer,Renato Tarchini,Sander Peters,Hans Sandbrink,Mark Fiers,Willem J. Stiekema,René Klein Lankhorst,Peter A. Bron,Sally M. Hoffer,Masja Nierop Groot,Robert Kerkhoven,Maaike C. de Vries,Björn M. Ursing,Willem M. de Vos,Roland J. Siezen +19 more
TL;DR: The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated from human saliva, has been determined, and contains 3,052 predicted protein-encoding genes, suggesting that these genes form a lifestyle adaptation region in the chromosome.
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Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants
Tanja Jaeggi,Guus A. M. Kortman,Diego Moretti,Christophe Chassard,Penny Holding,Alexandra Dostal,Jos Boekhorst,Harro M. Timmerman,Dorine W. Swinkels,Harold Tjalsma,Jane Njenga,AM Mwangi,Jane Kvalsvig,Christophe Lacroix,Michael B. Zimmermann +14 more
TL;DR: In this article, the effect of high and low dose in-home iron fortification on the infant gut microbiome and intestinal inflammation was determined by double-blind randomised controlled trials in 6-month-old Kenyan infants.
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Data mining in the Life Sciences with Random Forest: a walk in the park or lost in the jungle?
Wouter G. Touw,Jumamurat R. Bayjanov,Lex Overmars,Lennart Backus,Jos Boekhorst,Michiel Wels,Sacha A. F. T. van Hijum +6 more
TL;DR: Some of the to the best of the authors' knowledge rarely or never used RF properties that allow maximizing the biological insights that can be extracted from complex omics data sets using RF are detailed.
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Degenerate target sites mediate rapid primed CRISPR adaptation
Peter C. Fineran,Matthias J. H. Gerritzen,Maria Suarez-Diez,Tim Künne,Jos Boekhorst,Sacha A. F. T. van Hijum,Raymond H.J. Staals,Stan J. J. Brouns +7 more
TL;DR: It is shown that priming is an extremely robust process capable of using degenerate target regions, with up to 13 mutations throughout the PAM and protospacer region, and implies that even outdated spacers containing many mismatches can induce a rapid primed CRISPR response against diversified or related invaders.
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Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island
Willem van Schaik,Janetta Top,David R. Riley,Jos Boekhorst,Joyce E. P. Vrijenhoek,Claudia M. E. Schapendonk,Antoni P. A. Hendrickx,Antoni P. A. Hendrickx,Isaac J. Nijman,Marc J. M. Bonten,Hervé Tettelin,Rob J. L. Willems +11 more
TL;DR: Genes involved in environmental persistence, colonization and virulence can easily be aquired by E. faecium, which will make the development of successful treatment strategies targeted against this organism a challenge for years to come.