J
Janet M. Siliciano
Researcher at Johns Hopkins University School of Medicine
Publications - 20
Citations - 4026
Janet M. Siliciano is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Virus & Virus latency. The author has an hindex of 12, co-authored 20 publications receiving 3602 citations. Previous affiliations of Janet M. Siliciano include Howard Hughes Medical Institute & Johns Hopkins University.
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Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
Diana Finzi,Joel N. Blankson,Janet M. Siliciano,Joseph B. Margolick,Karen Chadwick,Theodore C. Pierson,Kendall A. Smith,Julianna Lisziewicz,Franco Lori,Charles Flexner,Thomas C. Quinn,Richard E. Chaisson,Eric S. Rosenberg,Bruce D. Walker,Stephen J. Gange,Joel E. Gallant,Robert F. Siliciano +16 more
TL;DR: The mean half-life of the latent reservoir was very long (43.9 months) and the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable as mentioned in this paper.
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International AIDS Society global scientific strategy: towards an HIV cure 2016
Steven G. Deeks,Sharon R Lewin,Anna Laura Ross,Jintanat Ananworanich,Monsef Benkirane,Paula M. Cannon,Nicolas Chomont,Daniel C. Douek,Jeffrey D. Lifson,Ying-Ru Lo,Daniel R. Kuritzkes,David M. Margolis,John W. Mellors,Deborah Persaud,Joseph D. Tucker,Françoise Barré-Sinoussi,Galit Alter,Judith D. Auerbach,Brigitte Autran,Dan H. Barouch,Georg M. N. Behrens,Marina Cavazzana,Zhiwei Chen,Éric A. Cohen,Giulio Maria Corbelli,Serge Eholié,Nir Eyal,Sarah Fidler,Laurindo Garcia,Cynthia I. Grossman,Gail E. Henderson,Timothy J. Henrich,Richard Jefferys,Hans-Peter Kiem,Joseph M. McCune,Keymanthri Moodley,Peter A. Newman,Monique Nijhuis,Moses Supercharger Nsubuga,Melanie Ott,Sarah Palmer,Douglas D. Richman,Asier Sáez-Cirión,Matthew G.F. Sharp,Janet M. Siliciano,Guido Silvestri,Jerome Amir Singh,Bruno Spire,Jeff Taylor,Martin Tolstrup,Susana T. Valente,Jan van Lunzen,Rochelle P. Walensky,Ira B. Wilson,Jerome A. Zack +54 more
TL;DR: A group of international experts to develop a scientific strategy for research towards an HIV cure summarized the group's strategy in this Perspective.
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Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes.
Yefei Han,Kara Lassen,Daphne Monie,Ahmad R. Sedaghat,Shino Shimoji,Xiao Liu,Theodore C. Pierson,Joseph B. Margolick,Robert F. Siliciano,Janet M. Siliciano +9 more
TL;DR: In inverse PCR, it is demonstrated that HIV-1 genomes reside within actively transcribed host genes in resting CD4+ T cells in vivo, and RT-PCR experiments confirmed the presence of HIV- 1 sequences within transcripts initiating upstream of the HIV-2 transcription start site.
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Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
Steven A. Yukl,Eli Boritz,Michael P. Busch,Christopher Bentsen,Tae Wook Chun,Daniel C. Douek,Evelyn E. Eisele,Ashley T. Haase,Ya Chi Ho,Gero Hütter,J. Shawn Justement,Sheila M. Keating,Tzong-Hae Lee,Peilin Li,Danielle Murray,Sarah Palmer,Christopher D. Pilcher,Satish K. Pillai,Richard W. Price,Meghan K Rothenberger,Timothy W. Schacker,Janet M. Siliciano,Robert F. Siliciano,Robert F. Siliciano,Elizabeth Sinclair,Matthew C. Strain,Joseph K. Wong,Douglas D. Richman,Steven G. Deeks +28 more
TL;DR: The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure.
Journal ArticleDOI
The multifactorial nature of HIV-1 latency
Kara G. Lassen,Yefei Han,Yan Zhou,Janet M. Siliciano,Robert F. Siliciano,Robert F. Siliciano +5 more
TL;DR: Latency might result from insufficient nuclear levels of the crucial activation-dependent host transcription factors required to overcome the transcriptional interference that is an automatic consequence of the nature of HIV-1 integration sites.