J
Joseph Ciccolini
Researcher at Aix-Marseille University
Publications - 190
Citations - 4514
Joseph Ciccolini is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 35, co-authored 167 publications receiving 3786 citations. Previous affiliations of Joseph Ciccolini include Centre national de la recherche scientifique & European Organisation for Research and Treatment of Cancer.
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Journal ArticleDOI
Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors
Maddalena Centanni,Dirk Jan A.R. Moes,Iñaki F. Trocóniz,Joseph Ciccolini,J. G. Coen van Hasselt +4 more
TL;DR: An overview of the pharmacokinetic (PK) aspects related to current ICIs, which include target-mediated drug disposition and time-varying drug clearance, and important issues related to the efficacy and safety, the pharmacodynamics, of ICIs are addressed, including exposure–response relationships related to clinical outcome.
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Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment
Eddy Pasquier,Joseph Ciccolini,Manon Carré,Sarah Giacometti,Raphaelle Fanciullino,Charlotte Pouchy,Marie-Pierre Montero,Cindy Serdjebi,Maria Kavallaris,Nicolas André +9 more
TL;DR: It is suggested that the use of propranolol concurrently with chemotherapy may improve the outcome of breast cancer patients, thus providing a strong rationale for the evaluation of this drug combination in prospective clinical studies.
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Computational oncology — mathematical modelling of drug regimens for precision medicine
Dominique Barbolosi,Joseph Ciccolini,Bruno Lacarelle,Fabrice Barlesi,Fabrice Barlesi,Nicolas André +5 more
TL;DR: The current achievements and limitations with regard to computational modelling of drug regimens are highlighted, and the potential future implementation of this strategy to achieve precision medicine in oncology is discussed.
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Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective.
TL;DR: Gemcitabine is an antimetabolite ranking among the most prescribed anticancer drugs worldwide and is a drug paradigmatic for constant searches of the scientific community to improve its administration through the development of personalized medicine in oncology.
Journal ArticleDOI
Mathematical Modeling of Cancer Immunotherapy and Its Synergy with Radiotherapy.
Raphaël Serre,Sebastien Benzekry,Laetitia Padovani,Christophe Meille,Nicolas André,Joseph Ciccolini,Fabrice Barlesi,Xavier Muracciole,Dominique Barbolosi +8 more
TL;DR: In this article, a discrete-time pharmacodynamic model of the combination of radiotherapy with inhibitors of the PD1-PDL1 axis and/or the CTLA4 pathway is described.