J
Joseph D. Butner
Researcher at Houston Methodist Hospital
Publications - 38
Citations - 739
Joseph D. Butner is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Cancer & Immunotherapy. The author has an hindex of 9, co-authored 32 publications receiving 516 citations. Previous affiliations of Joseph D. Butner include Sandia National Laboratories & University of New Mexico.
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Simulating cancer growth with multiscale agent-based modeling
TL;DR: Some of the most recent agent-based models that have provided insight into the understanding of cancer growth and invasion, spanning multiple biological scales in time and space are introduced and several experimentally testable hypotheses generated by those models are described.
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Mathematical modeling in cancer nanomedicine: a review
Prashant Dogra,Joseph D. Butner,Yao-Li Chuang,Sergio Caserta,Shreya Goel,C. Jeffrey Brinker,Vittorio Cristini,Vittorio Cristini,Zhihui Wang,Zhihui Wang +9 more
TL;DR: A comprehensive review of literature on mathematical modeling works that have been and are being employed towards a better understanding of nano-bio interactions for improved tumor delivery efficacy is presented.
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Mechanistic Modeling Identifies Drug-Uptake History as Predictor of Tumor Drug Resistance and Nano-Carrier-Mediated Response
Jennifer Pascal,Carlee E. Ashley,Carlee E. Ashley,Zhihui Wang,Terisse A. Brocato,Joseph D. Butner,Eric C. Carnes,Eric C. Carnes,Eugene J. Koay,C. Jeffrey Brinker,Vittorio Cristini,Vittorio Cristini +11 more
TL;DR: Analysis of the model reveals that nanocarrier-mediated delivery overcomes resistance to the free drug because of improved cellular uptake rates, and that dose response curves to nanoccarrier mediated drug delivery are equivalent to those for free-drug, but "shifted to the left;" that is, lower amounts of drug achieve the same cell kill.
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Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill
Zhihui Wang,Zhihui Wang,Romica Kerketta,Yao-Li Chuang,Prashant Dogra,Joseph D. Butner,Terisse A. Brocato,Armin Day,Rong Xu,Haifa Shen,Eman Simbawa,A. S. AL-Fhaid,S. R. Mahmoud,Steven A. Curley,Mauro Ferrari,Eugene J. Koay,Vittorio Cristini +16 more
TL;DR: Cancer treatment efficacy can be significantly enhanced through the elution of drug from nano-carriers that can temporarily stay in the tumor vasculature through a generalized space- and time-dependent mathematical model of drug transport and drug-cell interactions.
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Integrated PK-PD and agent-based modeling in oncology.
TL;DR: This review focuses on some of the most recent modeling studies building on a combined PK-PD and ABM approach that have generated experimentally testable hypotheses.