J
Joseph J. Eron
Researcher at University of North Carolina at Chapel Hill
Publications - 569
Citations - 49427
Joseph J. Eron is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Viral load & Population. The author has an hindex of 99, co-authored 511 publications receiving 44857 citations. Previous affiliations of Joseph J. Eron include Duke University.
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No Evidence that Ongoing HIV-Specific Immune Responses Contribute to Persistent Inflammation and Immune Activation in Persons on Long-Term ART
Adam R. Ward,Adam R. Ward,Allison S. Thomas,Eva M. Stevenson,Szu-Han Huang,Szu-Han Huang,Sheila M. Keating,Sheila M. Keating,Rajesh T. Gandhi,Deborah McMahon,Ronald J. Bosch,Bernard J.C. Macatangay,Joshua C. Cyktor,Joseph J. Eron,John W. Mellors,R. Brad Jones,R. Brad Jones +16 more
TL;DR: In this article, the potential role of the HIV-specific adaptive immune response, which also persists under ART, in driving levels of clinically relevant biomarkers was investigated, but the relationship between HIV persistence parameters and inflammatory biomarkers were not influenced by either HIVspecific T-cell responses or antibody levels.
Journal ArticleDOI
Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine.
Michael Jetsupphasuk,Michael G. Hudgens,Haidong Lu,Stephen R. Cole,Jessie K. Edwards,Adaora A. Adimora,Keri N. Althoff,Michael J. Silverberg,Peter F Rebeiro,Viviane D. Lima,Vincent C. Marconi,Timothy R. Sterling,Michael A. Horberg,M. John Gill,Mari M. Kitahata,Richard D. Moore,Raynell Lang,Kelly A. Gebo,Charles S. Rabkin,Joseph J. Eron +19 more
TL;DR: In this article , the authors employed statistical methods for precision medicine to estimate an optimal treatment rule that minimizes the 5-year risk of the composite outcome of AIDS-defining illnesses, serious non-AIDS events, and all-cause mortality.
Posted ContentDOI
HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy
Eva M. Stevenson,Adam R. Ward,Adam R. Ward,Ronald Truong,Allison S. Thomas,Szu-Han Huang,Szu-Han Huang,Thomas R. Dilling,Sandra Terry,John K. Bui,Talia M. Mota,Ali Danesh,Guinevere Q. Lee,Andrea Gramatica,Pragya Khadka,Winiffer D. Conce Alberto,Rajesh T. Gandhi,Deborah McMahon,Christina M. Lalama,Ronald J. Bosch,Bernard J.C. Macatangay,Joshua C. Cyktor,Joseph J. Eron,John W. Mellors,R. Brad Jones,R. Brad Jones +25 more
TL;DR: It is shown that T-cell responses to autologous reservoir viruses persist over years, and that the maintenance of HIV-Nef-specific responses was uniquely associated with residual frequencies of infected cells.
Journal ArticleDOI
878. Association between Anterior Nasal and Plasma SARS-CoV-2 RNA Levels and Hospitalization or Death for Non-Hospitalized Adults with Mild-to-Moderate COVID-19
Mark J. Giganti,Kara W. Chew,Joseph J. Eron,Jonathan Z. Li,Mauricio Pinilla,Carlee Moser,Arzhang Javan,William A. Fischer,Paul Klekotka,D. Margolis,David A. Wohl,Robert W. Coombs,Eric S. Daar,Davey M. Smith,Michael Hughes,Judith S. Currier +15 more
TL;DR: Chow et al. as mentioned in this paper used regression models to estimate the association between RNA level or detection and subsequent hospitalization/death within 28 days of enrollment and found that higher day 0 AN RNA was associated with an increasing risk of hospitalization or death.
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